Evidence map›Paper›PMID 41810674›Full record

Trial reportFood & function2026

NAFLD-related SNPs are linked to changes in liver fat, as measured by the CAP score, and serum lipids in response to a 3-week sugar-sweetened beverage intervention: a pilot study.

Faustina Therase Jeyaraj, Sai Sravani Vennam, Kendra Nelson, Katherine Watts, Lydia R Goss, Brea C Nance, Baba B Mass, Venkata Saroja Voruganti

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Food & function, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03783195 (Genetic-specific Effects of Fructose on Liver Lipogenesis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03783195 nacompletednot on this map

Genetic-specific Effects of Fructose on Liver Lipogenesis

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2019 to 2023Enrolled15ConditionsNAFLDArmsSugar drink
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Faustina Therase JeyarajNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. saroja@unc.edu.ORCID http://orcid.org/0000-0002-0014-3808
Sai Sravani VennamNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. saroja@unc.edu.
Kendra NelsonNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. saroja@unc.edu.ORCID http://orcid.org/0000-0002-4864-7482
Katherine WattsUniversity of North Carolina at Charlotte, Charlotte, NC, USA.
Lydia R GossNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. saroja@unc.edu.
Brea C NanceStandard Process Inc., Kannapolis, NC, USA.
Baba B MassNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. saroja@unc.edu.
Venkata Saroja VorugantiNutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA. saroja@unc.edu.ORCID http://orcid.org/0000-0002-8704-4529

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies show that increased consumption of sugar-sweetened beverages (SSBs) is linked to non-alcoholic fatty liver disease (NAFLD), a condition characterized by excess fat accumulation in hepatocytes. Genetic factors also influence NAFLD. We conducted a clinical trial (NCT03783195) to determine if SNPs related to NAFLD are associated with liver fat content and its changes in response to a 3-week SSB intervention in Caucasian adolescents and young adults. Fifteen participants (5 males and 10 females, mean age 25.5 ± 9 years) consumed a beverage daily for 3 weeks, consisting of fructose : glucose in a 60 : 40 ratio. Liver fat content was measured by transient elastography through the controlled attenuation parameter (CAP) score. At baseline, the CAP score was 212.5 ± 10.1 dB m

Indexed as

LipidsLiverNon-alcoholic Fatty Liver DiseasePolymorphism, Single NucleotideSugar-Sweetened BeveragesAdolescentAdultFemaleGenotypeHumansMalePilot ProjectsYoung AdultLipids

Identifiers

PMID41810674
PMCPMC12977174

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.