Evidence map›Paper›PMID 41811093›Full record

ArticleJournal of medicinal chemistry2026

Examination of Coligands in Mefloquine-Metal Complexes Reveals the Structural Determinants of Activity against

Wilmer Villarreal, Helenita Costa Quadros, Legna Colina-Vegas, Sammy Y Aboagye, Godwin Akpeko Dziwornu, Gabriel H Ribeiro, Ariane Isis Barros, Dawid Jakub Kucharski, Mahsa Rahbari, Christina Brandstädter and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Wilmer VillarrealUniversidade Federal de São Carlos, Departamento de Química, São Carlos, SP 13565-905, Brazil.
Helenita Costa QuadrosFundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, BA 40296-710, Brazil.
Legna Colina-VegasUniversidade Federal de São Carlos, Departamento de Química, São Carlos, SP 13565-905, Brazil.
Sammy Y AboagyeRush University Medical Center, Department of Microbial Pathogens and Immunity, Chicago, Illinois 60612, United States of America.
Godwin Akpeko DziwornuDrug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0003-1668-8818
Gabriel H RibeiroUniversidade Federal de São Carlos, Departamento de Química, São Carlos, SP 13565-905, Brazil.ORCID 0000-0003-0738-1638
Ariane Isis BarrosUniversidade Federal de Mato Grosso, Departamento de Solos e Engenharia Rural, Cuiabá, MT 78060-900, Brazil.
Dawid Jakub KucharskiDepartment of Organic and Medicinal Chemistry, Wrocław University of Technology, Wyb. Wyspiańskiego 26, Wrocław 50-370, Poland.ORCID 0000-0001-5074-4719
Mahsa RahbariBiochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, Giessen, 35392, Germany.
Christina BrandstädterBiochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University Giessen, Heinrich-Buff-Ring 26-32, Giessen, 35392, Germany.
Sarah D'AlessandroDipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Milan, 20133, Italy.
Nicoletta BasilicoDipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Universitá degli Studi di Milano, Milan, 20133, Italy.
Keabetswe MasikeSouth African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.
Nandi MehlalaSouth African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.
Joaquim Araújo NobregaUniversidade Federal de São Carlos, Departamento de Química, São Carlos, SP 13565-905, Brazil.
Victor M DeflonUniversidade de São Paulo, Instituto de Química de São Carlos, São Carlos, SP 13560-970, Brazil.ORCID 0000-0002-5368-6486
Maribel NavarroUniversidade Federal de Juiz de Fora, Departamento de Química, Juiz de Fora, MG 36036-900, Brazil.ORCID 0000-0002-8772-0312
Przemysław J BoratyńskiDepartment of Organic and Medicinal Chemistry, Wrocław University of Technology, Wyb. Wyspiańskiego 26, Wrocław 50-370, Poland.ORCID 0000-0002-7139-8568
Kelly ChibaleDrug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa.ORCID 0000-0002-1327-4727
David L WilliamsRush University Medical Center, Department of Microbial Pathogens and Immunity, Chicago, Illinois 60612, United States of America.
Alzir A BatistaUniversidade Federal de São Carlos, Departamento de Química, São Carlos, SP 13565-905, Brazil.
Diogo R M MoreiraFundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, BA 40296-710, Brazil.ORCID 0000-0003-3323-4404

Funding

Development of novel TGR inhibitors for the treatment of schistosomiasisR01AI177493 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Pavel A Petukhov, DAVID LEE WILLIAMS · 2024 to 2026
$2.3M
NIAID NIH HHS R01 AI177493
6 · The paper itself

Abstract

Mefloquine (MQ) is an important component for antiparasitic therapy. Herein, the synthesis and antiplasmodial and antischistosomal activities of MQ-metal complexes of the general formula [M(II)(L)(MQ)]PF

Indexed as

AntimalarialsCoordination ComplexesMefloquinePlasmodium falciparumSchistosoma mansoniAnimalsHumansMiceMultienzyme ComplexesNADH, NADPH OxidoreductasesPalladiumStructure-Activity RelationshipAntimalarialsCoordination ComplexesMefloquineMultienzyme ComplexesNADH, NADPH OxidoreductasesPalladiumthioredoxin glutathione reductase

Identifiers

PMID41811093
PMCPMC13126674

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.