ArticleAdvanced materials (Deerfield Beach, Fla.)2026
Rethinking Extracellular Vesicle Signaling.
Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Breaking barriers in peritoneal fibrosis: extracellular vesicles as promising diagnostic and therapeutic strategy.Annals of medicine · 2026Review
- Lipid nanoparticles and extracellular vesicles: emerging cell free therapeutic platforms for hepatobiliary cancers.Frontiers in cell and developmental biology · 2026Review
- Reply: Extracellular vesicle-mediated signalling in human rescueHuman reproduction open · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Extracellular vesicles mediate intercellular communication through transport of bioactive cargo from producing to recipient cells. Cellular uptake and subsequent cytoplasmic release of internal cargo is often emphasized as the main mechanism of extracellular vesicle-mediated signaling. This article highlights two alternate modes of extracellular vesicle signaling based on surface binding without internalization: 'bind-and-stay', and 'bind-and-leave'. The transient binding of extracellular vesicles to multiple cells, inducing downstream signaling in each, challenges the conventional "one-vesicle-one-cell" model. We provide a forward-looking perspective on the efficiency and effectiveness of extracellular vesicle signaling modes and outline techniques that could be leveraged to study these interactions moving forward. An improved understanding of extracellular vesicle signaling is necessary for advancing fundamental biology and therapeutic development.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.