Evidence map›Paper›PMID 41811192›Full record

ArticleeLife2026

A genome-wide MAGIC kit for recombinase-independent mosaic analysis in

Yifan Shen, Ann T Yeung, Payton Ditchfield, Elizabeth Korn, Rhiannon Clements, Xinchen Chen, Bei Wang, Zixian Huang, Michael Sheen, Parker A Jarman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Clonal Analysis inBio-protocol · 2026
    Article
  2. Tuning mitotic recombination with patterned DNA nicks for precision mosaic analysis.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yifan Shen *Department of Molecular Biology and Genetics, Cornell University, Ithaca, United States.ORCID https://orcid.org/0000-0002-3921-1011
Ann T Yeung *Department of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Payton DitchfieldDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Elizabeth KornDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Rhiannon ClementsDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Xinchen ChenDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Bei WangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.ORCID https://orcid.org/0000-0003-3002-3302
Zixian HuangDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Michael SheenDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Parker A JarmanDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.
Chun HanDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, United States.ORCID https://orcid.org/0000-0001-7319-8095

Funding

MAGIC tools for genome-wide mosaic analysis with existing Drosophila resources (Equipment Supplement 2023)R24OD031953 · OD · CORNELL UNIVERSITY · PI HAN, CHUN · 2022 to 2025
$3.1M
NIH HHS R24 OD031953NIH Office of the Director R24OD031953
6 · The paper itself

Abstract

Mosaic analysis has been instrumental in advancing developmental and cell biology. Most current mosaic techniques rely on exogenous site-specific recombination sequences that need to be introduced into the genome, limiting their application. Mosaic analysis by gRNA-induced crossing-over (MAGIC) was recently developed in

Indexed as

Crossing Over, GeneticDrosophilaMosaicismAnimalsCRISPR-Cas SystemsGenome, InsectRecombinasesRecombination, GeneticRNA, Guide, CRISPR-Cas SystemsRecombinasesRNA, Guide, CRISPR-Cas Systemsclonal analysisCRISPRdevelopmental biologyD. melanogastergeneticsgenomicsgRNAinterspecific hybridMAGICpericentromeric

Identifiers

PMID41811192
PMCPMC12978697

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.