Evidence map›Paper›PMID 41811196›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9-Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host.

Carolina S D Vieira, Wei Wang, Fernando Sanchez-Valdez, Jihyun Lim, Brooke E White, Camilla G S Souza, Rick L Tarleton, Marcia C Paes, Natalia P A Nogueira

Abstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Carolina S D VieiraLaboratório de Interação de Tripanossomatídeos e Vetores, Departamento de Bioquímica, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-3312-5171
Wei WangDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID https://orcid.org/0000-0001-7111-4687
Fernando Sanchez-ValdezDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID https://orcid.org/0000-0002-0045-0453
Jihyun LimDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID https://orcid.org/0000-0002-0583-371X
Brooke E WhiteDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID https://orcid.org/0000-0002-0441-1355
Camilla G S SouzaLaboratório de Interação de Tripanossomatídeos e Vetores, Departamento de Bioquímica, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0009-0000-9090-6874
Rick L TarletonDepartment of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia, USA.ORCID https://orcid.org/0000-0002-9589-5243
Marcia C PaesLaboratório de Interação de Tripanossomatídeos e Vetores, Departamento de Bioquímica, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-2247-8251
Natalia P A NogueiraLaboratório de Interação de Tripanossomatídeos e Vetores, Departamento de Bioquímica, IBRAG, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0003-3258-607X

Funding

Conselho Nacional Pesquisa (CNPq) SWE (Sanduíche no Exterior) 402419/2022-7Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 00x0ma614Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) 88887.311601/2018-00-2629/2018Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) E26/010.001706/2019Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) E26/010.100623/2018Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) E26/211.815/2021
6 · The paper itself

Abstract

Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes-unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets. Among them, phosphoenolpyruvate carboxykinase (PEPCK) plays a central role in succinic fermentation, the main pathway for NAD

Indexed as

Chagas DiseaseCRISPR-Cas SystemsMicrobodiesPhosphoenolpyruvate Carboxykinase (ATP)Protozoan ProteinsTrypanosoma cruziAnimalsEnergy MetabolismGlucoseMiceMitochondriaGlucosePhosphoenolpyruvate Carboxykinase (ATP)Protozoan ProteinsbioenergeticsCRISPR/Cas9infectionmetacyclogenesisphosphoenolpyruvate carboxykinaseTrypanosoma cruzi

Identifiers

PMID41811196
PMCPMC12978206

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.