ArticleAmerican journal of physiology. Heart and circulatory physiology2026
Modifying the structural substrate and progression of heart failure with preserved ejection fraction using a regular exercise regimen in pigs.
Stephanie L Samani, Shayne C Barlow, Lisa A Freeburg, Grayson M Catherwood, Amelia M Churillo, Traci L Jones, Jumanah Al-Soudi, Ricky Ruiz, Francesco K Yigamawano, Tarek Shazly and 2 more
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In one paragraphArticle in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Stephanie L SamaniDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Shayne C BarlowDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0003-1679-176X Lisa A FreeburgDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Grayson M CatherwoodDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Amelia M ChurilloDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Traci L JonesDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0009-0002-7827-3079 Jumanah Al-SoudiDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.
Ricky RuizDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0009-0003-4313-5298 Francesco K YigamawanoDepartment of Biomedical Engineering, College of Engineering and Computing, University of South Carolina, Columbia, South Carolina, United States.ORCID 0009-0000-1971-6680 Tarek ShazlyDepartment of Biomedical Engineering, College of Engineering and Computing, University of South Carolina, Columbia, South Carolina, United States.
Michael R ZileDivision of Cardiology, RHJ Department of Veterans Affairs Medical Center, Medical University of South Carolina, Charleston, South Carolina, United States.
Francis G SpinaleDepartment of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, South Carolina, United States.ORCID 0000-0003-0529-5605 Funding
The Center for Clinical and Translational Research at the University of South Carolina (CLINTRUSC)P20GM155896 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI JAMES R HEBERT, FRANCIS G SPINALE · 2024 to 2026
$9.5MFibroblast targeting for myocardial repairR01HL167994 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI FRANCIS G SPINALE · 2023 to 2026
$2.6MBLRD VA I01 BX000168BLRD VA I01 BX005320HHS | National Institutes of Health (NIH) P20GM155896HHS | National Institutes of Health (NIH) R01HL13765HHS | National Institutes of Health (NIH) R01HL67994NHLBI NIH HHS R01 HL167994NIGMS NIH HHS P20 GM155896U.S. Department of Veterans Affairs (VA) 5I01-BX000168U.S. Department of Veterans Affairs (VA) 5I01-BX005320
6 · The paper itselfAbstract
Heart failure (HF) with a preserved ejection fraction (HFpEF) arises from a persistent left ventricular (LV) pressure overload (LVPO) ultimately causing increased LV myocardial stiffness (Km) and resistance to LV filling resulting in increased pulmonary capillary wedge pressure (PCWP) and left atrial area (LAA). Increased LV collagen content (fibrosis) is a structural underpinning of this process. Although exercise programs have shown benefit in patients with HF, whether and to what degree an exercise program overlaid with progressive LVPO may alter HFpEF progression remains unclear. Pigs (25 kg) underwent progressive LVPO for 5 wk without (
Indexed as
Heart FailurePhysical Conditioning, AnimalStroke VolumeVentricular Function, LeftVentricular RemodelingAnimalsCollagenDisease Models, AnimalDisease ProgressionFemaleFibrosisMyocardiumSus scrofaSwineVentricular PressureCollagencollagenexercise trainingextracellular matrixhypertrophyLV diastolic dysfunction
Identifiers
PMID41811247
PMCPMC13059137
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