Red Clover (Trifolium pratense) Isoflavones Reduce Plasma Levels of Extracellular DNA and Histone Proteins in Rats with Experimental Type 2 Diabetes Mellitus.

K V Sokolova, D A Tukanov, I F Gette, S A S Aboushanab, E G Kovaleva, I G Danilova

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Article in Bulletin of experimental biology and medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

K V SokolovaUral Federal University Named after the First President of Russia B. N. Yeltsin, Yekaterinburg, Russia.

D A TukanovUral Federal University Named after the First President of Russia B. N. Yeltsin, Yekaterinburg, Russia. danil_tukanov@mail.ru.

I F GetteUral Federal University Named after the First President of Russia B. N. Yeltsin, Yekaterinburg, Russia.

S A S AboushanabUral Federal University Named after the First President of Russia B. N. Yeltsin, Yekaterinburg, Russia.

E G KovalevaUral Federal University Named after the First President of Russia B. N. Yeltsin, Yekaterinburg, Russia.

I G DanilovaUral Federal University Named after the First President of Russia B. N. Yeltsin, Yekaterinburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endogenous immunotropic factors that promote the development of non-infectious inflammation can act as pathogenetic targets in the development of new agents for the treatment and prevention of type 2 diabetes mellitus (T2DM). Nucleotide motifs circulating in the blood can activate the immune system, thus playing an important role in the pathogenesis of T2DM and its vascular complications. We studied the effect of isoflavones extracted from red clover flowers (Trifolium pratense) on the plasma levels of extracellular nucleic acids and histone proteins in rats with a model of T2DM. It was shown that oral administration of isoflavones for 1 month to animals with diabetes reduced the plasma content of extracellular DNA and histones, which was accompanied by restoration of the number of granulocytes and alleviation of glycemia.

Indexed as

Diabetes Mellitus, ExperimentalDiabetes Mellitus, Type 2HistonesIsoflavonesPlant ExtractsTrifoliumAnimalsBlood GlucoseExtrachromosomal DNAMaleRatsRats, WistarBlood GlucoseExtrachromosomal DNAHistonesIsoflavonesPlant Extractsexperimental diabetes mellitusextracellular DNAextracellular histone proteinsextracellular RNATrifolium pratense isoflavones

Identifiers

PMID41811407

DOI10.1016/j.clim.2012.04.006

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