Evidence map›Paper›PMID 41812059›Full record

ArticleStem cells (Dayton, Ohio)2026

LARP7 enhances the potential of dental pulp stem cells to promote peripheral nerve repair.

Zihan Yang, Guanlin Qu, Xiping Wang, Li Wang, Lu Chen, Guiqiang Fu, Wenze Chen, Zitong Yang, Wenjing Li, Yuqiong Zhou and 3 more

Abstract read
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In one paragraph

Article in Stem cells (Dayton, Ohio), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zihan YangDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, 200001, China.ORCID 0000-0003-1169-7889
Guanlin QuDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, 200001, China.
Xiping WangInstitute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, 325027, China.
Li WangDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, 200001, China.
Lu ChenDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, 200001, China.ORCID 0000-0002-3933-2980
Guiqiang FuStomatology Hospital and College, Key Laboratory of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, 230000, China.
Wenze ChenStomatology Hospital and College, Key Laboratory of Oral Diseases Research of Anhui Province, Anhui Medical University, Hefei, 230000, China.
Zitong YangZhejiang Chinese Medical University School of Medical Technology and Information Engineering, Hangzhou, 310053, China.
Wenjing LiDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, 200001, China.
Yuqiong ZhouDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, 200001, China.
Jiacheng JinTouro College of Dental Medicine at New York Medical College, Hawthorne, NY 10532, USA.
Linxi ZhouDepartment of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, 200001, China.
Duohong ZouDepartment of Oral Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, 200001, China.

Funding

Fundamental Research Funds for the Central Universities YG2023QNA23Fundamental Research Funds for the Central Universities YG2024LC05Fundamental Research Program Funding of Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine JYZZ253Fund of Department of Oral and Maxillofacial Surgery of Shanghai Ninth People's Hospital (2024-02)Institute of Biomaterials and Regenerative Medicine Joint ResearchMedicine Biological Sample Project from Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School YBKB202210National Key R&D Program of China 2024YFC2418600National Natural Science Foundation of China 32171347National Natural Science Foundation of China 92368111Original Exploration Project of Shanghai Ninth People's HospitalShanghai Jiao Tong University School of Medicine 2022LHA04Shanghai Jiao Tong University School of Medicine JYYC007Shanghai Science and Technology Program 24SF1905400Zhejiang Provincial Natural Science Foundation of China LQN25H140009
6 · The paper itself

Abstract

backgroundPeripheral nerve injuries (PNIs) present a persistent clinical challenge due to the intrinsically limited regenerative capacity of peripheral nerves. While dental pulp stem cells (DPSCs) exhibit significant neuroregenerative potential, their therapeutic efficacy is constrained by hostile microenvironments and inherent functional heterogeneity. Genetic modification may offer a promising strategy to enhance their therapeutic capabilities.

methodsDPSCs were induced toward neural lineage differentiation, and key gene candidates were identified through qRT-PCR. Lentiviral-mediated gene interference was performed to modulate target gene expression, followed by comprehensive analysis of differentiation outcomes using qRT-PCR, Western blotting, and immunofluorescence assays. RNA sequencing was employed to uncover associated signaling pathways, which were subsequently validated through pharmacological inhibition with specific inhibitors. The therapeutic efficacy of genetically engineered DPSCs was evaluated in a rat model of sciatic nerve crush injury, with neural regeneration quantitatively assessed via neuroelectrophysiological measurements and histological analyses.

resultsLARP7 positively regulated the Schwann cell-like differentiation of DPSCs, as well as their trophic and anti-inflammatory effects, thus enhancing its therapeutic effects on nerve repair and promoting functional recovery. Mechanistically, we found that LARP7 remodeled cytokine-cytokine receptor interactions, enhancing trophic support while attenuating proinflammatory responses, and activated the PI3K-Akt-mTOR signaling pathway, with ERBB4 serving as a critical downstream effector, promoting DPSCs differentiation into Schwann cell-like phenotypes.

conclusionsCollectively, LARP7-mediated changes in DPSCs establish a new therapeutic paradigm that addresses the limitations of current stem cell-based interventions and enables the development of standardized biotherapeutics for peripheral nerve repair.

Indexed as

Dental PulpNerve RegenerationPeripheral Nerve InjuriesStem CellsAnimalsCell DifferentiationHumansMaleRatsRats, Sprague-DawleySchwann CellsSciatic NerveSignal Transductionmesenchymal stem cellperipheral nerve injuriesregenerative medicinestem cell therapytissue regeneration

Identifiers

PMID41812059
PMCPMC13223745

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.