Evidence map›Paper›PMID 41812323›Full record

ArticleRenal failure2026

Pregnane X receptor mitigates aristolochic acid-induced acute kidney injury via p53 ubiquitination.

Qianfang Liu, Fei Deng, Anqun Chen, Yu Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qianfang LiuDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Human, China.
Fei DengKey laboratory of Kidney Disease and Blood Purification in Human Province, Changsha, Hunan, China.
Anqun ChenDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Human, China.
Yu LiuDepartment of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Human, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aristolochic acid (AA), commonly used in Chinese herbal medicine to treat various diseases, can cause acute kidney injury (AKI). The pregnane X receptor (PXR), a nuclear receptor, is involved in drug metabolism, carcinogenesis, inflammation, apoptosis, oxidative stress and energy metabolism. Here, we demonstrate that PXR plays a protective role in AA-induced AKI. First, PXR expression was dramatically decreased in mice and Boston University mouse proximal tubular (BUMPT) cells treated with AA. Overexpression of PXR in BUMPT cells alleviated apoptosis induced by AA

Indexed as

Acute Kidney InjuryAristolochic AcidsPregnane X ReceptorTumor Suppressor Protein p53AnimalsApoptosisHumansKetoconazoleKidney Tubules, ProximalMaleMiceMice, Inbred C57BLPregnenolone CarbonitrileUbiquitinationaristolochic acid IAristolochic AcidsKetoconazolePregnane X ReceptorPregnenolone CarbonitrileTrp53 protein, mouseTumor Suppressor Protein p53Acute kidney injurydrug-induced nephrotoxicityP53 ubiquitinationpregnane X receptorrenal tubular epithelial cells

Identifiers

PMID41812323
PMCPMC12981258

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.