Evidence map›Paper›PMID 41812727›Full record

ArticleJournal of sport and health science2026

A nutrient-hormone axis pivots an energy trade-off between resting thermogenesis and movement expenditure.

Patricia M Rusu, Okka Htin Aung, Andrea Y Chan, Yuqin Wu, Maria Almira S Cleofe, Adam J Trewin, Saveen Giri, Ashish Foollee, Saori A Flores, Moyra B Lemus and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of sport and health science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Patricia M RusuNutrient Metabolism & Signalling Laboratory, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Metabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Okka Htin AungNutrient Metabolism & Signalling Laboratory, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Metabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Andrea Y ChanNutrient Metabolism & Signalling Laboratory, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Metabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Yuqin WuNutrient Metabolism & Signalling Laboratory, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Metabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Maria Almira S CleofeNutrient Metabolism & Signalling Laboratory, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Metabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Adam J TrewinInstitute for Physical Activity and Nutrition, and School of Exercise and Nutrition Sciences, Deakin University, Burwood, VIC 3125, Australia.
Saveen GiriDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Ashish FoolleeNutrient Metabolism & Signalling Laboratory, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Saori A FloresNutrient Metabolism & Signalling Laboratory, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Moyra B LemusMetabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Physiology, Monash University, Clayton, VIC 3800, Australia.
Erika GreavesMetabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Physiology, Monash University, Clayton, VIC 3800, Australia.
Susanne HilleDepartment of Internal Medicine V, University of Kiel, Kiel 24105, Germany; German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Kiel 24105, Germany.
Garron T DoddDepartment of Anatomy & Physiology, The University of Melbourne, Parkville, VIC 3052, Australia.
Meagan J McGrathDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Metabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia.
Oliver J MüllerDepartment of Internal Medicine V, University of Kiel, Kiel 24105, Germany; German Center for Cardiovascular Research (DZHK), Partner site Hamburg/Kiel/Lübeck, Kiel 24105, Germany.
Aneta StefanidisMetabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Department of Physiology, Monash University, Clayton, VIC 3800, Australia.
Adam J RoseNutrient Metabolism & Signalling Laboratory, Monash University, Clayton, VIC 3800, Australia; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia; Metabolism, Diabetes & Obesity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia. Electronic address: adam.rose@monash.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe biological reason why mammals increase daily energy expenditure when consuming a protein-dilute diet is currently enigmatic. Recognizing that body weight is a chief determinant of movement economy, we hypothesized that there is an interaction between dietary protein dilution-induced resting energy expenditure and subsequent effects on body weight and energy expenditure during physical activity.

methodsUsing inbred and genetically modified mice and methods such as defined diet feeding, body composition analysis, indirect calorimetry combined with forced treadmill running or in-cage wheel running, tissue histological and molecular/biochemical analyses, we examined the interactions of diet and exercise biology.

resultsWe found that mice chronically fed a protein-dilute diet exhibited enhanced weight-bearing exercise ability, an effect directly linked to the improved movement economy. Mechanistically, this improved movement economy and exercise ability resulted from a reduction in adiposity and body weight, which was facilitated by the increased liver-derived fibroblast growth factor 21 (Fgf21) that promotion of brown adipose tissue thermogenesis. Overall, dietary protein dilution-induced thermogenesis and resulting improved movement economy enabled a differential budgeting of energy expenditure between active and inactive states, resulting in balanced total energy expenditure.

conclusionThe influence of liver-derived Fgf21 on brown adipose tissue thermogenesis and energy expenditure drives improved movement economy and weight-bearing exercise capability during chronic dietary protein dilution.

Indexed as

DietEconomyEnergyExerciseMetabolism

Identifiers

PMID41812727
PMCPMC13199892

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.