ArticleThe Journal of biological chemistry2026
C-mannosyl tryptophan dynamics in a mouse model of the peritoneal dissemination of ovarian cancer.
Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
C-Mannosyl tryptophan (C-Man-Trp), a unique monomeric glycosyl amino acid, is up-regulated in the blood of ovarian cancer patients; however, the underlying mechanisms remain unclear. In the present study, C-Man-Trp production and its dynamics were investigated in female B6C3F1 mice transplanted with mouse ovarian cancer OV2944-HM-1 (HM-1) cells. After transplantation, C-Man-Trp levels increased in the plasma, urine, ascites, peritoneal exudate cells (PECs), and tumor masses of mice. Furthermore, changes in the transcriptional expression of C-Man-Trp metabolism-related genes, C-mannosyltransferases (Dpy19l1 and Dpy19l3), and thrombospondin type I repeat superfamily genes (Thbs1, Spon1, and cellular communication network factor 1) were noted in tumor-associated cells and tissues. A cell-sorting analysis revealed that PECs mainly comprised myeloid-derived immune cells, such as macrophages and myeloid-derived suppressor cells, in addition to a small population of HM-1 tumor cells. C-Man-Trp levels were high in the macrophage fraction, but lower in the myeloid-derived suppressor cell fraction. C-Man-Trp was also produced in the ex vivo culture medium of macrophages isolated from PECs. Under macrophage depletion using clodronate liposomes, the ovarian cancer-stimulated up-regulation of C-Man-Trp was significantly suppressed in the plasma, ascites, PECs, and tumor masses of HM-1 cell-transplanted mice. C-Man-Trp levels in the plasma and peritoneal cavity cells of normal healthy mice were also suppressed by clodronate liposomes, whereas the expression of C-Man-Trp metabolism-related genes showed different changes from those in mice transplanted with HM-1 cells. Collectively, these results demonstrate that tumor-stimulated macrophages play a pivotal role in the dynamics of C-Man-Trp in mice with ovarian cancer.
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