ArticleDiabetes research and clinical practice2026
Basal metabolic rate and risk for diabetes and its complications among 341,790 adults from the UK Biobank.
Article in Diabetes research and clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
aimsBasal metabolic rate (BMR) and energy imbalance are determinants of diabetes. We assessed the BMR-associated risk for diabetes in a large cohort.
methodsCox proportional models estimated hazard ratios (HR) for subsequent diabetes and its complications with estimated BMR among diabetes-free participants. The mediating role of vascular-metabolic biomarkers were assessed.
findingsAmong 341,790 participants aged 55.7 ± 8.1 years, the mean (standard deviation [SD]) estimated BMR was 1849 (234) kcal/day in men and 1340 (147) kcal/day in women. Over 12 years follow-up, 4,626 cases of diabetes accrued. Higher estimated BMR showed positive associations with diabetes, with each SD higher estimated BMR associated with a 55% increase in diabetes risk (HR 1.54, 95% confidence interval [CI] 1.49-1.59 in men; HR 1.56, 1.49-1.62 in women), and a substantive risk for cardiac complications among those with diabetes (1.71, 1.55-1.89 in men; 1.78, 1.56-2.03 in women), diabetic coma, ketoacidosis and glycaemic disturbances (1.18, 0.99-1.42 in men; 1.35, 1.21-1.50 in women), and stroke (1.27, 1.08-1.50 in men; 1.41, 1.14-1.76 in women). Glycated haemoglobin, triglycerides, high-density-cholesterol, Cystatin-C and C-reactive protein explained 10-30% of these associations.
conclusionEstimated elevated BMR was strongly positively associated with risk for diabetes and its complications, suggesting to re-evaluate the role of BMR, in addition to BMI, in diabetes research.
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