Evidence map›Paper›PMID 41813656›Full record

ArticleInternational journal of oral science2026

Defining subcellular synovial responses in TMJ osteoarthritis onset via mechanical stress and articular disk derangement models.

Kazuhiro Shibusaka, Soichiro Negishi, Asuka Terashima, Miki Maemura, Hiroshi Yoshida, Masahiro Hosonuma, Nobuhiro Sakai, Young Kwan Kim, Yutaka Suzuki, Hiroyuki Okada and 1 more

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Article in International journal of oral science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kazuhiro ShibusakaDepartment of Biochemistry, Graduate School of Dentistry, Showa Medical University, Shinagawa-ku, Tokyo, Japan.
Soichiro NegishiDepartment of Biochemistry, Graduate School of Dentistry, Showa Medical University, Shinagawa-ku, Tokyo, Japan.
Asuka TerashimaBone and Cartilage Regenerative Medicine, The University of Tokyo Hospital, Bunkyo-ku, Tokyo, Japan.
Miki MaemuraDepartment of Biochemistry, Graduate School of Dentistry, Showa Medical University, Shinagawa-ku, Tokyo, Japan.
Hiroshi YoshidaDepartment of Orthodontics, Graduate School of Dentistry, Showa Medical University, Ota-ku, Tokyo, Japan.ORCID 0000-0002-6792-1774
Masahiro HosonumaDepartment of Pharmacology, Graduate School of Pharmacy, Showa Medical University, ai, Shinagawa-ku, Tokyo, Japan.
Nobuhiro SakaiDivision of Dental Education, School of Dentistry, Showa Medical University, Shinagawa-ku, Tokyo, Japan.
Young Kwan KimDepartment of Biosystems Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan.
Yutaka SuzukiDepartment of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwa-shi, Chiba, Japan.
Hiroyuki OkadaCenter for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID 0000-0003-4217-1548
Fumiko YanoDepartment of Biochemistry, Graduate School of Dentistry, Showa Medical University, Shinagawa-ku, Tokyo, Japan. fumikoyano@dent.showa-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temporomandibular joint osteoarthritis (TMJ-OA), the most common degenerative disease of the TMJ, is influenced by various adaptive, inflammatory, and mechanical stressors. In this study, we describe molecular alterations of the synovium of the articular disk in response to mechanical and inflammatory stimuli. Using an integrated transcriptomic approach combining subcellular spatial transcriptomics and single-cell RNA sequencing in murine models of mechanical stress and articular disk derangement, we characterized synovial changes associated with adipogenesis, fibrosis, and macrophage activation. In addition, cell type-and cluster-specific catabolic changes were observed under these stress conditions, suggesting potential contributions to TMJ-OA onset. These results provide a methodology-oriented resource for investigating the molecular pathology of TMJ disorders and may help guide future studies toward the development of targeted therapeutic strategies.

Indexed as

OsteoarthritisStress, MechanicalSynovial MembraneTemporomandibular Joint DiscTemporomandibular Joint DisordersAnimalsDisease Models, AnimalMiceSpatial Transcriptomics

Identifiers

PMID41813656
PMCPMC12979832

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.