Evidence map›Paper›PMID 41813666›Full record

ArticleBone research2026

Factor VIII restores bone parameters and modulates muscle proteo-metabolome in Factor VIII knockout male mice.

Antoine Babuty, Javier Muñoz-Garcia, Olivier D Christophe, Laurie Fradet, Manon Taupin, Denis Cochonneau, Emilie Ollivier, Frank Driessler, Claudia Lange, Oleksandr Boychenko and 2 more

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In one paragraph

Article in Bone research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antoine Babuty *Nantes University Hospital, Department of Hemostasis, Nantes, France.
Javier Muñoz-Garcia *Nantes Université, CNRS, UMR6286, US2B, 2 Rue de la Houssinière, 44322, Nantes, France.ORCID 0000-0002-2978-1192
Olivier D ChristopheINSERM, Université Paris-Saclay, U1176, Paris, France.
Laurie FradetNantes Université, CNRS, UMR6286, US2B, 2 Rue de la Houssinière, 44322, Nantes, France.
Manon TaupinInstitut de Cancérologie de l'Ouest, Pathology Research Platform, Saint-Herblain, France.
Denis CochonneauInstitut de Cancérologie de l'Ouest, Heterogeneity and Precision Medicine laboratory, Blvd Jacques Monod, 44805, Saint-Herblain, France.
Emilie OllivierInstitut de Cancérologie de l'Ouest, Heterogeneity and Precision Medicine laboratory, Blvd Jacques Monod, 44805, Saint-Herblain, France.
Frank DriesslerBayer Consumer Care AG, TA Medical Affairs Hematology, Basel, Switzerland.
Claudia LangeBayer AG, Precision Medicine Markers, Berlin, Germany.
Oleksandr BoychenkoBayer AG, Translational Sciences/Omics Research, Wuppertal, Germany.ORCID 0000-0003-1765-170X
Marie-Françoise HeymannNantes Université, CNRS, UMR6286, US2B, 2 Rue de la Houssinière, 44322, Nantes, France.
Dominique HeymannNantes Université, CNRS, UMR6286, US2B, 2 Rue de la Houssinière, 44322, Nantes, France. dominique.heymann@univ-nantes.fr.ORCID 0000-0001-7777-0669

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to its role in hemostasis, Factor VIII (FVIII) has recently been shown to potentially impact angiogenesis, inflammation, osteopenia, and sarcopenia. This was explored here by studying the musculoskeletal development of FVIII knockout (FVIII

Indexed as

Bone and BonesFactor VIIIMetabolomeMuscle, SkeletalAnimalsMaleMiceMice, KnockoutPhenotypeProteomicsFactor VIII

Identifiers

PMID41813666
PMCPMC12979855

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.