Evidence mapPaperPMID 41813872Full record

ReviewMetabolomics : Official journal of the Metabolomic Society2026

Outcomes and future activities of the 'Pan-European network in Lipidomics and EpiLipidomics - EpiLipidNET'.

Julia Kuligowski, Justine Bertrand-Michel, Amaury Cazenave-Gassiot, Laura Goracci, Pedro Domingues, Matej Orešič, Margret Thorsteinsdottir, Florian Gruber, Egon L Willighagen, Corinne M Spickett and 11 more

Abstract readReview
In one paragraph

Review in Metabolomics : Official journal of the Metabolomic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Julia KuligowskiSpanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS- SAMID) (RD24/0013/0014), Neonatal Research Group, Health Research Institute La Fe, Avenida Fernando Abril Martorell 106, Valencia, 46026, Spain. julia.kuligowski@uv.es.ORCID http://orcid.org/0000-0001-6979-2235
Justine Bertrand-MichelMetaboHUB-MetaToul, National Infrastructure of Metabolomics and Fluxomics, 31077, Toulouse, France.ORCID http://orcid.org/0000-0001-9815-1517
Amaury Cazenave-GassiotDepartment of Biochemistry and Precision Medicine TRP, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117456, Singapore.ORCID http://orcid.org/0000-0002-3050-634X
Laura GoracciDAISY Lab, Department of Chemistry, Biology and Biotechnology, University of Perugia, Via dell' Elce di Sotto 8, Perugia, 06123, Italy.ORCID http://orcid.org/0000-0002-9282-9013
Pedro DominguesMass Spectrometry Center, Department of Chemistry, LAQV-REQUIMTE, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal.ORCID http://orcid.org/0000-0002-8060-7675
Matej OrešičSchool of Medical Sciences, Örebro University, Örebro, Sweden.ORCID http://orcid.org/0000-0002-2856-9165
Margret ThorsteinsdottirFaculty of Pharmaceutical Sciences, University of Iceland, Sturlugata 8, 102 , Reykjavik, Iceland.ORCID http://orcid.org/0000-0002-0649-8503
Florian GruberDepartment of Dermatology, CDL SKINMAGINE, Medical University of Vienna, Währinger Gürtel 18-20, Vienna, 1090, Austria.ORCID http://orcid.org/0000-0003-1094-5641
Egon L WillighagenDepartment of Translational Genomics, NUTRIM, Maastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0000-0001-7542-0286
Corinne M SpickettAston University & Aston Institute for Membrane Excellence, Aston Triangle, Birmingham, B4 7ET, UK.ORCID http://orcid.org/0000-0003-4054-9279
Tatjana RuskovskaFaculty of Medical Sciences, Goce Delcev University, Krste Misirkov, 10A, 2000, Stip, 2000, North Macedonia.ORCID http://orcid.org/0000-0002-4300-4891
Valerie B O'DonnellSystems Immunity Research Institute, School of Medicine, Cardiff University, Cardiff, CF14 4XN, UK.ORCID http://orcid.org/0000-0003-4089-8460
Patricia PrabutzkiMaastricht MultiModal Molecular Imaging Institute (M4i), Maastricht University, Maastricht, The Netherlands.ORCID http://orcid.org/0009-0002-7472-6843
Snježana PetrovićCentre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, National Institute of Republic of Serbia, University of Belgrade, Dr. Subotica 4, 11129, Belgrade, Serbia.ORCID http://orcid.org/0000-0002-1387-9777
Joanna GodzienMetabolomics and Proteomics Laboratory, Clinical Research Centre, Medical University of Bialystok, Marii Skłodowskiej-Curie 24 A, 15-276 Bialystok, Bialystok, Poland.ORCID http://orcid.org/0000-0002-9477-057X
Sara TortorellaMass Analytica SL, Av. Cerdanyola 92-94, 08173, Sant Cugat del Vallés, Spain.ORCID http://orcid.org/0000-0001-9691-8323
Ana ReisREQUIMTE, University of Porto, Porto, Portugal.
Irundika H K DiasMedical School, Aston University, Birmingham, UK.ORCID http://orcid.org/0000-0002-6620-8221
Guy SchleyerDepartment of Marine Microbiology and Biogeochemistry, NIOZ Royal Netherlands Institute for Sea Research, Texel, The Netherlands.ORCID http://orcid.org/0000-0001-9756-9356
Rosário DominguesMass Spectrometry Center, Department of Chemistry, LAQV-REQUIMTE, University of Aveiro, Campus Universitário de Santiago, Aveiro, 3810-193, Portugal. mrd@ua.pt.ORCID http://orcid.org/0000-0001-5357-3601
Maria FedorovaCenter of Membrane Biochemistry and Lipid Research, University Hospital and Faculty of Medicine Carl Gustav Carus of TU Dresden, Tatzberg 47/49, 01307, Dresden, Germany. maria.fedorova@tu-dresden.de.ORCID http://orcid.org/0000-0002-4692-3885

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLipidomics and its branch epilipidomics are rapidly advancing fields that explore the roles of native and modified lipids (e.g., oxidized, nitrated and halogenated lipid species), respectively, in biological systems. Dysregulation of lipid metabolism and signaling contributes to numerous diseases, including cardiovascular, metabolic, neurodegenerative, and inflammatory conditions. However, multiple challenges, including lack of standardization, limited data integration, and poor clinical translation, hinder progress. To address these, the COST Action EpiLipidNET (CA19105) established a pan-European network fostering collaboration across disciplines to accelerate lipid science and its application to health and disease. AIM OF REVIEW: This review outlines the achievements of EpiLipidNET over its four-year duration, highlights key scientific contributions across five thematic working groups, and presents the future direction of its ongoing activities. The aim is to demonstrate how a collaborative, interdisciplinary framework can catalyze innovation in lipidomics and epilipidomics, enhance methodological harmonization, support early-career researchers, and bridge the gap between basic science, clinical translation, industry, stakeholders, and public engagement. KEY SCIENTIFIC CONCEPTS OF REVIEW: EpiLipidNET structured its networking activities around (i) harmonization of analytical workflows, (ii) development of epilipidomics tools and data integration strategies, (iii) translational studies for clinical lipid biomarkers, (iv) investigation of lipid signaling mechanisms, and (v) dissemination and outreach. The network supported over 460 members globally, launched multiple training schools and scientific missions, produced 110+ publications, and fostered new initiatives in endothelial membrane lipidomics, food lipidomics, plant and algae lipids, and redox lipid biology. Its integrative approach sets a foundation for continued progress toward precision medicine and sustainable health interventions through lipid science.

Indexed as

Lipid MetabolismLipidomicsMetabolomicsEuropeHumansLipidsLipidsCollaborative networkCOST actionEpilipidomeLipidomics

Identifiers

PMID41813872
PMCPMC12979403

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.