ArticleNutrition & metabolism2026
Multiple B vitamins dynamics during pregnancy and the risk of immediate postpartum anemia: a longitudinal birth cohort study.
Article in Nutrition & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPostpartum anemia is a global health issue linked to maternal mortality and sepsis. While iron deficiency plays a role, its contribution is limited, highlighting the need for better biomarkers. Although some studies suggest potential links between certain B vitamins and anemia, their relationship with immediate postpartum anemia (IPPA) remains unclear. We aimed to explore the longitudinal trajectory patterns of B vitamins (B1, B2, B3, B5, B6, and B9) during pregnancy and their potential associations with IPPA, and to develop a preliminary predictive model based on identified factors.
methodsWe recruited 200 women in second trimester, measuring B vitamin levels longitudinally through pregnancy and postpartum. IPPA was defined as hemoglobin < 11 g/dL within 24 h postpartum. Latent class trajectory models (LCTM) identified B vitamin trajectories, and logistic regression analyzed associations with IPPA. A predictive model for IPPA risk was developed using the Kolmogorov-Arnold network (KAN), with performance evaluated via the area under the curve (AUC), the net reclassification index (NRI), integrated discrimination improvement (IDI), and decision curve analysis (DCA).
resultsIPPA was diagnosed in 52.5% of participants. Unique trajectories of vitamins B1 (OR 0.25, 95% CI 0.10–0.59) and B3 (OR 0.21, 95% CI 0.08–0.57) were associated with reduced IPPA risk. Single-time-point analyses indicated that second-trimester levels of B1 (OR 0.82, 95% CI 0.67–0.98) and B3 (OR 0.84, 95% CI 0.73–0.97) may be associated with lower IPPA risk. The predictive model, integrating second-trimester levels of B1, B3, and iron, achieved an AUC of 0.78 (95% CI 0.76–0.79). The KAN-based predictive model showed an NRI of 0.32 (95% CI 0.27–0.37) and an IDI of 0.08 (95% CI 0.07–0.09), indicating superior predictive performance compared to the base model.
conclusionsOur exploratory findings suggest that B vitamins, particularly the previously unrecognized vitamin B3, may play a protective role against IPPA, with the second trimester emerging as a potential critical window for monitoring. The developed predictive model shows promise as a screening tool. These results require validation in larger prospective studies but point to modifiable nutritional factors that could inform future prevention strategies.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.