ArticleBMC sports science, medicine & rehabilitation2026
Differences in neuromuscular function of the ankle joint following lateral ankle sprain between copers and cai individuals: a systematic review and meta-analysis.
Article in BMC sports science, medicine & rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neuromuscular characteristics of individuals with chronic ankle instability during unilateral landing tasks: a meta-analysis of electromyographic studies.Journal of orthopaedic surgery and research · 2026Pooled it
- Intelligent Rehabilitation: Advances in Artificial Intelligence for Musculoskeletal Rehabilitation: A Narrative Review.Orthopedic research and reviews · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveCompare neuromuscular alterations of the ankle joint between individuals with chronic ankle instability (CAI) and copers who both experienced lateral ankle sprain (LAS) to examine the functional differences and guide rehabilitation strategies.
designSystematic review and meta-analysis. DATA SOURCE: A comprehensive search of PubMed, Web of Science, Embase, SPORTDiscus, and Scopus databases from inception to 1 December, 2025. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Observational studies and randomized controlled trials (RCTs) comparing neuromuscular function between copers and CAI patients were included.
resultsFifteen studies including 627 participants were analyzed. Meta-analysis showed CAI individuals exhibited delayed peroneus longus (PL) latency (g = -1.17, 95% CI: -1.62 to -0.73), and increased tibialis anterior (TA) and medial gastrocnemius (MG) activation (g = -0.49 and g = -0.35, respectively) compared to copers. No significant differences were observed in PL activation or co-contraction indices. Muscle morphology and performance showed inconsistent outcomes across studies, preventing meta-analysis.
conclusionFindings from meta-analyses indicate that copers exhibit different neuromuscular functional alterations compared to individuals with CAI. However, whether these alterations are compensations in response to LAS is still unclear. Clarifying this distinction may inform understanding of CAI development and generate hypotheses for future rehabilitation research.
trial registrationCRD42024623852. Date of Registration 19.12.2024.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.