The Effects of SGLT2 Inhibitors on Muscle Health in Older Adults: A Systematic Review and Meta-Analysis.

Weena Joongpan, Nittaya Boonmuen, Pimthong Sinchai, Sarawut Lapmanee, Natawat Klamsakul, Nutthapoom Pathomthongtaweechai

Abstract readSystematic ReviewMeta-Analysis

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Synthesis in Pharmacology research & perspectives, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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6 authors.

Weena JoongpanDepartment of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

Nittaya BoonmuenDepartment of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

Pimthong SinchaiDepartment of Physiology, Faculty of Science, Mahidol University, Bangkok, Thailand.

Sarawut LapmaneeChulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.

Natawat KlamsakulDepartment of Mathematics, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok, Thailand.

Nutthapoom PathomthongtaweechaiChakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand.ORCID 0000-0003-4641-5829

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Type 2 diabetes mellitus (T2DM) and obesity are growing global health concerns, particularly in older adults who are at higher risk of sarcopenia. While sodium-glucose cotransporter 2 (SGLT2) inhibitors show promise for glycemic control and weight loss, their effects on muscle health remain unclear. We examined the effects of SGLT2 inhibitors on body weight, fat mass, and muscle mass in T2DM patients. We systematically searched the PubMed, Embase, Scopus, and Cochrane databases for relevant randomized controlled trials (RCTs). Three reviewers screened the studies, and two extracted data and assessed their quality. R software was used to evaluate heterogeneity via Cochran's Q and I

Indexed as

Diabetes Mellitus, Type 2Muscle, SkeletalSodium-Glucose Transporter 2 InhibitorsAgedBenzhydryl CompoundsBody WeightGlucosidesHumansObesityRandomized Controlled Trials as TopicSarcopeniaWeight LossBenzhydryl CompoundsempagliflozinGlucosidesSodium-Glucose Transporter 2 Inhibitorsagingmuscle massSGLT2 inhibitortype 2 diabetes mellitusweight reduction

Identifiers

PMID41814443

DOI10.1002/prp2.70232

PMCPMC13140511

What Socratic holds

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LicenceCC BY

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.