Metal-Ligand Interactions: Overlooked Confounders in Antibiotic Discovery and Development.

Ziyi Jia, Moyosore Oluseyi Orimoloye, Courtney C Aldrich, Anthony D Baughn

Abstract read

In one paragraph

Article in ACS infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ziyi JiaDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota 55455, United States.

Moyosore Oluseyi OrimoloyeDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis Minnesota 55455, United States.ORCID 0000-0002-0330-008X

Courtney C AldrichDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis Minnesota 55455, United States.ORCID 0000-0001-9261-594X

Anthony D BaughnDepartment of Microbiology and Immunology, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0003-1188-4238

Funding

Targeting trans-translation to kill M. tuberculosis non-replicating persister cellsR01AI158706 · NIAID · UNIVERSITY OF TEXAS AT AUSTIN · PI ANTHONY D BAUGHN, Kenneth C Keiler · 2022 to 2026

$3.4M

NIAID NIH HHS R01 AI158706

6 · The paper itself

Abstract

The unabating rise of antimicrobial resistance makes the development of novel and effective antibiotics an urgent global health need. Progress toward assuaging this need is, however, limited by low levels of investment and patently low financial incentives. Eliminating inefficiencies in antibiotic development is therefore important to ensure effective deployment of limited resources. Metal interference in high-throughput assays, mechanism of action studies, and the eventual pharmacokinetics of antibiotics in development is an overlooked confounder in this process. In this Viewpoint, we, focusing on antibiotics, briefly provide a compartment-based approach to anticipating various possibilities for such interference and recommend toolkits for identification.

Indexed as

Anti-Bacterial AgentsDrug DiscoveryMetalsBacteriaDrug DevelopmentHigh-Throughput Screening AssaysHumansLigandsAnti-Bacterial AgentsLigandsMetals

Identifiers

PMID41814542

DOI10.1021/acsinfecdis.6c00148

PMCPMC13340868

What Socratic holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.