Evidence map›Paper›PMID 41814627›Full record

ArticleHuman brain mapping2026

The Regulation of Vasomotor and Cardiorespiratory Pulsations Is Disrupted in Primary Central Nervous System Lymphoma: A Case-Control fMRI Study.

Valter Poltojainen, Matti Järvelä, Nina Keinänen, Michaela K Bode, Juha-Matti Isokangas, Hanne Kuitunen, Juha Nikkinen, Vesa Korhonen, Niko Huotari, Lauri Raitamaa and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Valter PoltojainenOulu Functional NeuroImaging-(OFNI), Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.ORCID https://orcid.org/0000-0003-1105-1076
Matti JärveläOulu Functional NeuroImaging-(OFNI), Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.
Nina KeinänenAnesthesiology, Oulu University Hospital, Oulu, Finland.
Michaela K BodeDepartment of Diagnostic Radiology, Oulu University Hospital, Research Unit of Health Sciences and Technology (HST), University of Oulu, Oulu, Finland.ORCID https://orcid.org/0000-0002-1083-6990
Juha-Matti IsokangasDepartment of Diagnostic Radiology, Oulu University Hospital, Research Unit of Health Sciences and Technology (HST), University of Oulu, Oulu, Finland.
Hanne KuitunenOncology and Hematology, Oulu University Hospital, Oulu, Finland.
Juha NikkinenDepartment of Diagnostic Radiology, Oulu University Hospital, Research Unit of Health Sciences and Technology (HST), University of Oulu, Oulu, Finland.
Vesa KorhonenOulu Functional NeuroImaging-(OFNI), Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.ORCID https://orcid.org/0000-0001-9403-4583
Niko HuotariOulu Functional NeuroImaging-(OFNI), Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.
Lauri RaitamaaOulu Functional NeuroImaging-(OFNI), Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.
Janne KananenOulu Functional NeuroImaging-(OFNI), Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.
Heta HelakariOulu Functional NeuroImaging-(OFNI), Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.ORCID https://orcid.org/0000-0002-4354-4687
Tommi Kalevi KorhonenNeurosurgery, Clinical Neuroscience, University of Oulu/Oulu University Hospital, Oulu, Finland.
Sami TetriNeurosurgery, Clinical Neuroscience, University of Oulu/Oulu University Hospital, Oulu, Finland.
Outi KuittinenCancer Center, Kuopio University Hospital, Kuopio, Finland.ORCID https://orcid.org/0000-0001-9969-0053
Vesa KiviniemiOulu Functional NeuroImaging-(OFNI), Research Unit of Health Sciences and Technology, University of Oulu, Oulu, Finland.ORCID https://orcid.org/0000-0003-0184-8524

Funding

Academy of Finland Project 338599Academy of Finland TERVA 314497Academy of Finland TERVA 335720Arvo and Lea Ylppö FoundationEmil Aaltosen SäätiöFinnish Brain FoundationFinnish Cultural FoundationFinnish Medical FoundationFinnish Medical Society DuodecimInstrumentariumin TiedesäätiöInstrumentarium Science FoundationJane and Aatos Erkko FoundationJuhani Aho Medical Research FoundationMaire Taposen SäätiöMedical Research Center OuluOrion Research FoundationSuomalainen Lääkäriseura DuodecimSuomen KulttuurirahastoSuomen Lääketieteen SäätiöTauno Tönningin Säätiö
6 · The paper itself

Abstract

Primary central nervous system lymphoma (PCNSL) alters (peri)vascular structures while increasing vasomotor and cardiorespiratory pulsations within the brain. Vasomotor pulsations may arise from amplitude modulations of respiratory (RPE) and cardiovascular (CHE) pulsations while cardiovascular fluctuations may be modulated by respiration through cardiorespiratory amplitude modulation (CREM). In this study, we examined glymphatic cerebrospinal fluid convection in brains of PCNSL patients by assessing these waves. Thirty PCNSL patients (median 66y; 9 females) and 40 healthy age-matched controls (median 62y; 29 females) were scanned using an fMRI-based MREG

Indexed as

BrainCentral Nervous System NeoplasmsGlymphatic SystemLymphomaRespirationVasomotor SystemAgedCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle Agedlymphomamalignancyphysiologypulsation

Identifiers

PMID41814627
PMCPMC13093760

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.