ArticleJournal of diabetes research2026
Personalized Optimal Fat Intake for Glycemic Health: Evidence of a U-Shaped Association and Heterogeneity From NHANES.
Article in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Personalized Optimal Fat Intake for Glycemic Health: Evidence of a U-Shaped Association and Heterogeneity From NHANES.Journal of diabetes research · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe optimal dietary fat intake for glycemic control is debated. We investigated the dose-response relationship between the fat energy ratio and HbA1c, determined an optimal level, and assessed effect modification by age and diabetes status.
methodsThis cross-sectional study included 6639 U.S. adults from NHANES 2017-2020. The fat energy ratio was derived from two 24-h dietary recalls. Associations with HbA1c were assessed using restricted cubic splines and multivariable regression, adjusting for sociodemographic, lifestyle, clinical, and dietary covariates.
resultsA significant nonlinear, U-shaped association was identified (P - nonlinearity < 0.01). The optimal fat intake for minimal HbA1c was 36.0% (95% CI: 32.1-38.2). Stratified analyses revealed effect modification: the optimal ratio was higher in middle-aged (45-64 years: 36.9%) versus younger (18-44 years: 32.2%) and older adults (≥ 65 years: 32.7%), and in individuals with diabetes (38.0%) who exhibited a pronounced U-shaped curve, unlike the flat association seen in those without diabetes.
conclusionGlycemic control exhibits a U-shaped relationship with dietary fat, with an overall optimum at 36.0% of energy. The ideal intake is context-dependent, being higher in middle-aged and diabetic populations, supporting personalized dietary guidelines over universal fat intake targets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.