Evidence mapPaperPMID 41815047Full record

ReviewJournal of diabetes research2026

Breathomics in Diabetes Management: A Noninvasive Approach for Precision Health Monitoring.

Nathiya Ranganathan, J Geetha, Anbarasu Krishnan, A S Vickram, A Saravanan, Jeganathan Chinnadurai, Yi-Hsun Chen, Wei-Chung Chen, I-Chen Wu, Vinoth Kumar Ponnusamy and 1 more

Abstract readReview
In one paragraph

Review in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nathiya RanganathanDepartment of Microbiology, Auxilium College (Autonomous), Vellore, Tamil Nadu, India, auxiliumcollege.edu.in.ORCID https://orcid.org/0000-0002-1037-4036
J GeethaDepartment of Microbiology, Auxilium College (Autonomous), Vellore, Tamil Nadu, India, auxiliumcollege.edu.in.ORCID https://orcid.org/0009-0004-2941-8424
Anbarasu KrishnanDepartment of Bioinformatics, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, India, saveetha.com.ORCID https://orcid.org/0000-0002-8467-6352
A S VickramDepartment of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, India, saveetha.com.ORCID https://orcid.org/0000-0003-4319-1575
A SaravananDepartment of Biotechnology, Saveetha School of Engineering, Saveetha Institute of Medical and Technical Sciences (SIMATS), Chennai, Tamil Nadu, India, saveetha.com.ORCID https://orcid.org/0000-0002-5420-8662
Jeganathan ChinnaduraiPhD Program in Life Sciences, College of Life Sciences, Kaohsiung Medical University (KMU), Kaohsiung, Taiwan.ORCID https://orcid.org/0009-0004-7522-2377
Yi-Hsun ChenDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, kmuh.org.tw.ORCID https://orcid.org/0000-0001-9981-5143
Wei-Chung ChenDepartment of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, kmu.edu.tw.
I-Chen WuDivision of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, kmuh.org.tw.ORCID https://orcid.org/0000-0002-6260-0402
Vinoth Kumar PonnusamyDepartment of Medicinal and Applied Chemistry, Kaohsiung Medical University (KMU), Kaohsiung, Taiwan.ORCID https://orcid.org/0000-0003-2112-2085
Selvakumar PalaniappanDepartment of Food Technology, School of Applied Sciences, Papua New Guinea University of Technology, Lae, Papua New Guinea, unitech.ac.pg.ORCID https://orcid.org/0000-0002-0813-894X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rising prevalence of diabetes necessitates accurate, noninvasive methods for early detection and personalized management. Breathomics, the investigation of exhaled volatile organic compounds (VOCs), offers a promising approach for evaluating glycemic control, oxidative stress, and metabolic alterations associated with diabetes. Specific VOCs, such as acetone, isoprene, and ethanol, reflect glucose fluctuations, lipid oxidation, and insulin sensitivity, linking metabolic changes to real-time physiological states. Recent analytical advancements in gas chromatography-mass spectrometry, proton transfer reaction-mass spectrometry, and electronic nose technologies have enhanced the reliability and clinical applicability of breath-based assessments. The investigations focus on integrating VOC-based metabolic signatures with lifestyle and behavioral factors to establish a precision, noninvasive framework for diabetes management. This review also discusses key challenges that remain in standardizing breath analysis techniques, interpreting complex breath data, and implementing breath-based technology into personalized diabetes management. Breathomics provides a novel pathway for dynamic real-time assessment of metabolic health, bridging physiological biomarkers with lifestyle responses to enable individualized diabetes management.

Indexed as

Diabetes MellitusPrecision MedicineVolatile Organic CompoundsBiomarkersBreath TestsDigital HealthGas Chromatography-Mass SpectrometryHumansMonitoring, PhysiologicBiomarkersVolatile Organic Compoundsbreathomicsdiabetes managementlifestyle interventionnoninvasive diagnosticspersonalized medicinevolatile organic compounds

Identifiers

PMID41815047
PMCPMC13140305

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.