Evidence map›Paper›PMID 41815094›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

TEAD1 Enhances Exosome Secretion and Promotes Exosome-Mediated Tissue Regeneration.

Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yan PuClinical Research Center for Cell-based Immunotherapy of Shanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai, China.
Yi WanClinical Research Center for Cell-based Immunotherapy of Shanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai, China.
Wenhao ShiAnalysis Center, Chemistry Department, Tsinghua University, Beijing, China.
Bin LiDepartment of Spine Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haiyue ZhangDepartment of Cancer Research Institute, Xinjiang Key Laboratory of Translational Biomedical Engineering, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China.
Jun WuCAS Center for Excellence in Molecular Cell Science, Cell Bank, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Lingling LiClinical Research Center for Cell-based Immunotherapy of Shanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai, China.
Wenjia GuoDepartment of Cancer Research Institute, Xinjiang Key Laboratory of Translational Biomedical Engineering, Affiliated Cancer Hospital of Xinjiang Medical University, Urumqi, China.
Chen DingClinical Research Center for Cell-based Immunotherapy of Shanghai Pudong Hospital, Fudan University Pudong Medical Center, State Key Laboratory of Genetics and Development of Complex Phenotypes, School of Life Sciences, Human Phenome Institute, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-8673-3464
Wenjun YangDepartment of Pediatric Orthopedics, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-0324-1649

Funding

China Postdoctoral Science Foundation 2023M740297China Postdoctoral Science Foundation 2024T170176Development Funds of Zhangjiang National Independent Innovation Demonstration Zone ZJ2019-ZD004Human Phenome Data Center of Fudan UniversityKey R&D Program in Xinjiang Uygur Autonomous Region 2022B03019-4National Key R&D Program of China 2022YFA1303200National Key R&D Program of China 2022YFA1303201National Natural Science Foundation of China 31972933National Natural Science Foundation of China 32300974National Natural Science Foundation of China 32330062National Natural Science Foundation of China 32401234National Natural Science Foundation of China 82272166Program of Shanghai Academic/Technology Research Leader 22XD1420100Shanghai Municipal Science and Technology Major Project 2023SHZDZX02Shanghai Phenomic Precision Measurement Professional Technical Service Platform 23DZ2290800
6 · The paper itself

Abstract

Exosomes serve as intercellular communication vectors and are involved in a broad range of physiological functions. Although exosome-based therapies have demonstrated diverse functional potential, the regulatory mechanisms underlying their biogenesis and secretion remain poorly understood. Here, we report that TEAD1 functions as a molecular switch, dramatically enhancing the synthesis and secretion of exosomes. Mechanistically, TEAD1 enhances exosome secretion by promoting the expression of exosome secretion-associated proteins RAB11, CD9, and SNAP23. We found that TEAD1 enhances exosome secretion from adipose-derived mesenchymal stem cells, thereby promoting skin wound healing in diabetic mice. Similarly, TEAD1 promotes the release of exosomes from bone marrow-derived mesenchymal stem cells, thereby facilitating spinal cord injury (SCI) repair. Our study elucidates a novel role for TEAD1 in driving exosome secretion in different cell types, highlighting the therapeutic potential of TEAD1 in enhancing tissue regeneration, particularly in diabetic wound healing and SCI repair.

Indexed as

DNA-Binding ProteinsExosomesRegenerationSpinal Cord InjuriesTranscription FactorsWound HealingAnimalsHumansMesenchymal Stem CellsMiceTEA Domain Transcription FactorsDNA-Binding ProteinsTEAD1 protein, humanTead1 protein, mouseTEA Domain Transcription FactorsTranscription Factorsexosomespinal cord injury repairTEAD1wound healing

Identifiers

PMID41815094
PMCPMC13137834

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.