How combined PFAS (per- and polyfluoroalkyl substances) and metals may contribute to chronic obstructive pulmonary disease.

Aderonke Ayodele, Emmanuel Obeng-Gyasi

Abstract read

In one paragraph

Article in International public health journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aderonke AyodeleDepartment of Built Environment and Environmental Health and Disease Laboratory, North Carolina A&T State University, Greensboro, North Carolina, USA.

Emmanuel Obeng-GyasiDepartment of Built Environment and Environmental Health and Disease Laboratory, North Carolina A&T State University, Greensboro, North Carolina, USA.

Funding

The Impact of Combined Exposure to Metals and Per- and Polyfluoroalkyl Substances on Stress, Cardiovascular Disease Risk and MortalityR16GM149473 · NIGMS · NORTH CAROLINA AGRI & TECH ST UNIV · PI Emmanuel Obeng-Gyasi · 2023 to 2026

$650k

NIGMS NIH HHS R16 GM149473

6 · The paper itself

Abstract

This paper explores the combined impact of PFAS (per- and polyfluoroalkyl substances) and heavy metals on respiratory health, focusing on their potential synergistic or additive effects. Evidence suggests that co-exposure to these contaminants might exacerbate pulmonary inflammation, oxidative stress, and lung injury. Studies indicate that PFAS and heavy metals, both known for their persistence and bioaccumulation in the environment, can disrupt immune responses, increase susceptibility to respiratory infections, and contribute to the development and exacerbation of COPD (chronic obstructive pulmonary disease). Given the limited research on the joint effects of PFAS and metals, this paper aims to fill the knowledge gap by providing insights into their interactive effects on respiratory health. It underscores the importance of regulatory measures to limit emissions of these contaminants and public health initiatives to reduce exposure. By addressing the combined impact of PFAS and metals, effective strategies can be developed to protect respiratory health and mitigate the risks associated with environmental pollutants.

Indexed as

COPDexposomemetalsPFASrespiratory

Identifiers

PMID41815215

PMCPMC12974849

What Socratic holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.