ArticleMaterials today. Bio2026
A sequential defense-nourishment strategy enabled by thermosensitive core-shell microneedles for synergistic tendon repair.
Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A Thermosensitive Hydroxybutyl Chitosan/Microalgae Hydrogel With Antibacterial and Antioxidant Activities for Accelerating Burn Wound Healing.Macromolecular bioscience · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Achilles tendon rupture is a common sports injury, yet clinical tendon repair remains challenging. Current therapeutic approaches lack the ability to temporally regulate the injury microenvironment, hindering the synergy between anti-inflammatory defense and tissue regeneration. To address this, an innovative "sequential defense nutrition" synergistic strategy based on thermosensitive core-shell microneedles is proposed for efficient repair of complex tendon injuries. The study designed and fabricated core-shell microneedles using thermosensitive hydroxybutyl chitosan (HBC) as the matrix, with a core encapsulating growth factor-rich platelet-rich plasma (PRP) and a shell loaded with a proanthocyanidin-copper metal-phenolic network (PCCu) possessing both antioxidant and antibacterial functions. Leveraging the temperature-responsive gelation of HBC, this intelligent delivery system achieves stable anchoring and sustained release after implantation, overcoming the limitation of conventional delivery systems that are prone to displacement in deep tissue. At the injury site, the PCCu in the shell rapidly releases first, clearing reactive oxygen species (ROS) and inhibiting bacterial proliferation to swiftly establish an anti-inflammatory and anti-infective microenvironment. Subsequently, the PRP core provides programmed sustained release of growth factors, continuously supplying bioactive signals necessary for the proliferation and differentiation of tendon-derived stem cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.