Evidence map›Paper›PMID 41816072›Full record

ArticleQuantitative imaging in medicine and surgery2026

Imaging features of porto-sinusoidal vascular disorder in a case-control study: diagnostic value for differentiation from liver cirrhosis.

Fengxiang Song, Haoxiang Zhu, Lijun Qian, Zhiyu Zeng, Meng Li, Jinyu Wang, Meilin Zhu, Li Li, Min Yuan, Yunfei Lu and 16 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Fengxiang Song *Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Haoxiang Zhu *Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
Lijun Qian *Department of Radiology, Renji Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Zhiyu ZengDepartment of Hepatobiliary Disease, 900th Hospital of Joint Logistics Support Force, Fuzhou, China.
Meng LiInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jinyu WangDepartment of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
Meilin ZhuDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Li LiThe Clinical Research Center for Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Min YuanDepartment of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Yunfei LuDepartment of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yang HeDepartment of Interventional and Vascular Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, China.
Long ChenDepartment of Traditional Chinese Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Nannan ShiDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xiong MaDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease; Institute of Aging & Tissue Regeneration, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Chenyi JiangDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory for Oncogenes and Related Genes, Renji Hospital, School of Medicine, Shanghai Jiao Tong University; Shanghai Institute of Digestive Disease, Shanghai, China.
Dongliang LiDepartment of Hepatobiliary Disease, 900th Hospital of Joint Logistics Support Force, Fuzhou, China.
Jing LvDepartment of Liver Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Chenghai LiuInstitute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Weifeng ZhaoDepartment of Infectious Diseases, the First Affiliated Hospital of Soochow University, Suzhou, China.
Meng ZhangDepartment of Infectious Diseases, the First Affiliated Hospital of Soochow University, Suzhou, China.
Ying YuanThe Clinical Research Center for Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Fei ShanDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jiawen ZhangDepartment of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Jiming ZhangDepartment of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.
Qingchun Fu *The Clinical Research Center for Liver Disease, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yuxin Shi *Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Porto-sinusoidal vascular disorder (PSVD) is often misdiagnosed as liver cirrhosis due to overlapping clinical presentations and imaging features. This study conducted a blinded, independent imaging review to identify and compare the distinct imaging features between the two diseases, and to develop and validate a predictive model for differentiating PSVD from cirrhosis. Methods: Patients with histologically and clinically confirmed PSVD or cirrhosis and available contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) scans were retrospectively enrolled in the study. Imaging features were independently and systematically analyzed by two abdominal radiologists, who were blinded to the case grouping. Inter-reader discrepancies were resolved by consensus. The key features for analysis included liver surface nodularity (LSN), regenerative nodules (RNs), signs of portal hypertension (PH), and reticular delayed enhancement of the hepatic parenchyma. CT, MRI, and combined predictive models were developed to identify the top performing model, which was then selected and validated on an independent test cohort. Model performance was evaluated based on the area under the curve (AUC), sensitivity, and specificity. Results: In total, 106 patients with PSVD and 104 patients with cirrhosis were included for imaging evaluation and model development. The data of an additional 36 patients with PSVD and 51 patients with cirrhosis were collected for independent model testing. PSVD exhibited the same pronounced PH imaging features as cirrhosis, including grade 1-3 splenomegaly (77/106, 72.6% Conclusions: Patients presenting with severe PH imaging features but lacking typical cirrhosis imaging features should be thoroughly evaluated for PSVD. MRI is the preferred imaging modality. Our MRI-based predictive model reliably differentiates PSVD from cirrhosis, offering a non-invasive method for enhancing the suspicion of PSVD.

Indexed as

cirrhosiscomputed tomography (CT)Livermagnetic resonance imaging (MRI)porto-sinusoidal vascular disorder (PSVD)

Identifiers

PMID41816072
PMCPMC12971336

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.