ReviewInternational journal of women's health2026
Impact of Side Effects on 5-Year Adherence to Adjuvant Endocrine Therapy in Women with Breast Cancer: An Integrative Review.
Review in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Autonomous motivation and adherence intention in long-term breast cancer treatment: a self-determination theory model.Breast (Edinburgh, Scotland) · 2026Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Extending adjuvant endocrine therapy (AET) from 5 to 10 years has been shown to improve disease-free survival (DFS) in hormone receptor-positive (HR+) women with breast cancer. However, adherence to AET for 5 years remains suboptimal, with side effects frequently identified as a major contributing factor. Additionally, the impact of side effects on 5-year adherence has rarely been comprehensively explored. Purpose: This review aimed to consolidate studies published in English or Chinese on the side effects of AET and their impact on 5-year adherence in women with breast cancer. Methods: This integrative review followed Whittemore and Knafl's five-stage framework. Seven electronic databases (Medline, Cochrane Library, Embase, CINAHL, PsycINFO, Scopus and China National Knowledge Infrastructure) were searched from their inception to February 2025, following strict inclusion and exclusion criteria. Methodological quality was evaluated using the Mixed Methods Appraisal Tool (version 2018). Results: Thirty-four eligible articles were included, comprising 20 quantitative, 12 qualitative, and two mixed-methods studies. The 5-year AET adherence ranged from 46% to 93.6%, with a consistent decline over time. Musculoskeletal and joint pain, hot flashes, personal images, sleep issues, and emotional disturbances were the most common side effects. Although the number and severity of side effects have been identified as critical factors affecting adherence, the impact of side effects on AET adherence has been inconsistent across studies. Current studies lack standardized methods for measuring adherence and clear distinctions between the side effects of different AETs. Many women reported inadequate understanding and strategies for managing side effects, which not only diminished their quality of life (QoL) but also led to premature discontinuation. Conclusion: Future research should explore a comprehensive, multi-method adherence instrument and differentiate the side effects of various AETs. Targeted interventions are required to support women better and improve their long-term adherence to AET.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.