ArticleFrontiers in nutrition2026
The impact of dietary inflammation index on benign prostatic hyperplasia: insights from patient data and animal models.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Commentary: The impact of dietary inflammation index on benign prostatic hyperplasia: insights from patient data and animal models.Frontiers in nutrition · 2026Article
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6 authors.
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Abstract
Background: Benign prostatic hyperplasia (BPH) is a common chronic condition among elderly males, typically manifesting as lower urinary tract symptoms (LUTS), including increased urinary frequency, urgency, nocturia, urinary stream splitting, and dysuria. Previous reports have indicated a potential association between dietary habits and BPH; however, the specific causal relationship between dietary factors and prostatic hyperplasia remains unclear. Therefore, this study aimed to investigate the potential causal relationship between the dietary inflammation index (DII) and BPH through a cross-sectional cohort analysis, two-sample Mendelian randomization (TS-MR), and complementary animal experiments. Methods: DII and BPH were defined using data from the National Health and Nutrition Examination Survey (NHANES), and their association was investigated. We then used TS-MR to screen nine dietary preferences and evaluate their causal effects on BPH risk. To validate these findings, we conducted external dietary interventions on rats according to three dietary patterns (baseline diet group, pro-inflammatory diet group, and anti-inflammatory diet group) to modulate dietary preferences, and assessed prostatic hyperplasia as well as systemic and local inflammation in the rats using H&E, Masson, and IHC staining, and ELISA assays. Results: Higher DII scores were significantly associated with increased BPH risk (fully adjusted OR = 1.07, 95% CI: 1.03-1.12, Conclusion: Our integrated population-based, genetic, and experimental evidence supports a causal role of dietary inflammatory load in the development of BPH. Chronic consumption of pro-inflammatory diets may promote BPH through sustained systemic and prostate-specific inflammation, while anti-inflammatory dietary patterns may confer protective effects. These findings highlight the potential of dietary modulation as a preventive and therapeutic strategy for BPH management.
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