Evidence map›Paper›PMID 41816299›Full record

ArticleiScience2026

Integrated multi-omics reveals population-specific mechanisms of cardiovascular disease in high-altitude environments.

Weiyu Meng, Jiajun Yang, Xi Wang, Xiaobing Zhai, Gang Luo, Yuyang Sha, Hongxin Pan, Wei Xu, Henry H Y Tong, Edmundo Patricio Lopes Lao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Weiyu MengCenter for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau SAR 999078, Macao.
Jiajun YangDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Xi WangMedical College, Tibet University, Lhasa, Tibet 850000, China.
Xiaobing ZhaiCenter for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau SAR 999078, Macao.
Gang LuoCenter for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau SAR 999078, Macao.
Yuyang ShaCenter for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau SAR 999078, Macao.
Hongxin PanCenter for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau SAR 999078, Macao.
Wei XuCenter for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau SAR 999078, Macao.
Henry H Y TongCenter for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau SAR 999078, Macao.
Edmundo Patricio Lopes LaoDepartment of Cardiology, Macao Health Bureau, Macau SAR 999078, Macao.
Ci-Ren Zhong-GaDepartment of Cardiology, Lhasa People's Hospital, Lhasa, Tibet 850000, China.
Song CuiDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Xiantao SongDepartment of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
Kefeng LiCenter for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macau SAR 999078, Macao.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-altitude populations exhibit lower cardiovascular disease incidence and mortality with significant differences between indigenous highlanders and migrants. However, related genetic adaptation and population-specific mechanisms remain underexplored. We conducted a comprehensive multi-omics investigation of three cardiovascular disease patient cohorts from distinct altitudes: indigenous high-altitude residents (IHA,

Indexed as

human physiologyomics

Identifiers

PMID41816299
PMCPMC12972740

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.