Evidence mapPaperPMID 41816331Full record

ReviewFrontiers in immunology2026

Osteoporosis and gut microbiota: current understandings.

Yikai Liu, Shuai Lu, Ruifeng Bai, Pengli Han, Yejun Zha, Xieyuan Jiang

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. PasteurizedFrontiers in immunology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yikai Liu *Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, China.
Shuai Lu *Department of Orthopaedics and Traumatology, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, China.
Ruifeng BaiDepartment of Laboratory, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, China.
Pengli HanPharmaceutical Department, Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, China.
Yejun ZhaDepartment of Orthopaedics and Traumatology, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, China.
Xieyuan JiangDepartment of Orthopaedics and Traumatology, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoporosis (OP), a prevalent disease among middle-aged and elderly individuals, is characterized by a decrease in bone mineral density (BMD), which predisposes individuals to fragile fractures. The core pathological process involves excessive bone resorption over bone formation. The etiology of OP is intricate, and increasing recent studies have focused on the role of gut microbiota (GM) in its pathogenesis. Harmful bacteria exacerbate OP, whereas probiotics are beneficial for bone metabolism and delay the progression of OP. GM influences the progression of OP through various mechanisms, including the production of metabolites, modulation of the intestinal barrier, and regulation of intestinal immunity and osteoimmunology. In this review, we summarize the role of GM in the pathogenesis of OP based on the latest understandings, and highlight the promising potential of strategies targeting GM for the intervention and management of OP.

Indexed as

Gastrointestinal MicrobiomeOsteoporosisAnimalsBone and BonesHumansProbioticsbone metabolismgut microbiotaleaky gutosteoporosisprobiotics

Identifiers

PMID41816331
PMCPMC12971907

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.