ArticleJournal of thoracic disease2026
Rehabilitation effects of high-intensity interval training on asthma: a systematic review and meta-analysis of randomized controlled trials.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
3 authors.
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Abstract
Background: High-intensity interval training (HIIT) has demonstrated benefits in cardiometabolic health, but its efficacy and safety in asthma rehabilitation remain controversial due to inconsistent findings from existing randomized controlled trials (RCTs). This systematic review and meta-analysis aims to synthesize the latest evidence. Methods: Following PRISMA 2020 guidelines, we systematically searched PubMed, Embase, Web of Science, and the Cochrane Library up to June 2025 for RCTs comparing HIIT against control conditions (including passive controls and active interventions like moderate-intensity continuous training) in individuals with asthma. Primary outcomes were the Asthma Control Questionnaire (5-item version) (ACQ-5), peak oxygen uptake (VO Results: Seven RCTs (n=518 participants) were included. The meta-analysis demonstrated no statistically significant benefits of HIIT over control conditions for ACQ-5 (SMD: -1.19; 95% CI: -2.69 to 0.32; P=0.12), VO Conclusions: Current evidence does not conclusively establish the superior efficacy of HIIT over conventional rehabilitation or control conditions for asthma management. The pooled effect estimates are highly uncertain due to extreme clinical and methodological heterogeneity stemming from varied HIIT protocols, diverse control groups, and heterogeneous patient populations. Therefore, the findings should be interpreted with caution. Future high-quality RCTs with standardized interventions, rigorous safety monitoring, and phenotypic stratification are needed to define the role of HIIT in asthma rehabilitation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.