Evidence map›Paper›PMID 41816502›Full record

ReviewTherapeutic advances in psychopharmacology2026

Psychedelic therapy and postpartum depression: priorities and prospects.

Guillaume Thuery, Frank Crossen, Daniel Mc Loone, Catherine Hinds, Richard Duffy, Chaitra Jairaj, Andrew Harkin, John R Kelly

Abstract readReview
In one paragraph

Review in Therapeutic advances in psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trials, trips, and tribulations: pathways for implementing psychedelic therapy in Ireland.The international journal of neuropsychopharmacology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guillaume ThueryTrinity Institute of Neurosciences, Trinity College Dublin, Dublin, Ireland.
Frank CrossenSchool of Medicine, Trinity College Dublin, Ireland.
Daniel Mc LooneTrinity Institute of Neurosciences, Trinity College Dublin, Dublin, Ireland.
Catherine HindsThe National Maternity Hospital, Dublin, Ireland.
Richard DuffySchool of Medicine, University College Dublin, Belfield, Dublin, Ireland.
Chaitra JairajThe Coombe Hospital, Dublin, Ireland.
Andrew HarkinTrinity Institute of Neurosciences, Trinity College Dublin, Dublin, Ireland.
John R KellyTrinity Institute of Neurosciences, Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0002-9545-0615

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Approximately 15% of pregnant women experience postpartum depression (PPD). Even with currently available antidepressant treatments, many women will continue to be impaired by symptoms. Psychedelic therapy offers a promising transdiagnostic therapeutic strategy for several mental health disorders, and early results from current trials suggest that serotonergic psychedelics may represent a viable therapeutic approach for PPD. However, there is marked variability in the therapeutic response to psychedelic therapy, and the benefit-risk ratio in this population is not yet clear. To inform the rationale for the use of serotonergic psychedelics in the treatment of PPD, this review summarises the existing knowledge of immune, endocrine and neural pathways underpinning PPD and explores how serotonergic psychedelics interact with these pathways in the context of maternal motivation, bonding and caregiving behaviours. Finally, special considerations for psychedelic therapy in the postpartum period are outlined and future perspectives explored. Despite the rationale and encouraging early findings, further research is required to determine efficacy and safety profiles. Future studies, particularly longitudinal trials, should include adaptations and safeguards tailored to the unique physiological, psychological and caregiving contexts of the postpartum period.

Indexed as

5-MeO-DMTmajor depressionpostpartum depressionpsilocybinpsychedelics

Identifiers

PMID41816502
PMCPMC12972557

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.