Evidence map›Paper›PMID 41816928›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Language deficits across PET-based Braak stages of tau accumulation in Alzheimer's disease.

Anna Marier, Jaime Fernández Arias, Étienne Aumont, Brandon J Hall, Arthur C Macedo, Nesrine Rahmouni, Gleb Bezgin, Paolo Vitali, Pedro Rosa-Neto, Maxime Montembeault

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anna MarierDouglas Research Centre, Montréal, Quebec, Canada.
Jaime Fernández AriasDepartment of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
Étienne AumontDepartment of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
Brandon J HallDepartment of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
Arthur C MacedoDepartment of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
Nesrine RahmouniDepartment of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
Gleb BezginDepartment of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
Paolo VitaliMcGill University Research Centre for Studies in Aging, Montréal, Quebec, Canada.
Pedro Rosa-NetoDepartment of Neurology and Neurosurgery, McGill University, Montréal, Quebec, Canada.
Maxime MontembeaultDouglas Research Centre, Montréal, Quebec, Canada.ORCID 0000-0002-9369-0498

Funding

Brain Canada Foundation 33397Brain Canada Foundation CFI Project 34874Canadian Consortium of Neurodegeneration and Aging MOP-11-51-31-team1CIHR 159815CIHR 162303CIHR MOP-11-51-31CIHR RFN 152985Fonds de Recherche du Québec- Santé 2020-VICO-279314Weston Brain Institute and the Alzheimer's Association NIRG-12-92090Weston Brain Institute and the Alzheimer's Association NIRP-12-259245
6 · The paper itself

Abstract

introductionLanguage complaints in cognitively unimpaired (CU) individuals may reflect Alzheimer's Disease (AD) pathology and future objective impairments.

methods211 participants (138 CU, 45 with mild cognitive impairment (MCI), and 28 with dementia) from the TRIAD cohort underwent

resultsComplaints about forgetting the names of objects appeared in early tau stages (Braak 1-2), followed by naming difficulties (Braak 3-4), and widespread language impairments in later stages (Braak 5-6). Across the biologically-defined AD continuum, lower language performance was associated with tau accumulation predominantly in left-temporal language regions. In CU, only subjective word-finding complaints related to tau, indicating language concerns could reflect underlying pathology before measurable cognitive decline. DISCUSSION: Language measures support early detection and staging of AD pathophysiology and contribute to better align cognitive assessment with biological definitions of the disease.

Indexed as

Alzheimer DiseaseLanguage Disorderstau ProteinsAgedAged, 80 and overBrainCognitive DysfunctionFemaleHumansMaleNeuropsychological TestsPositron-Emission Tomographytau ProteinsAlzheimerbiomarkerscognitive declinefluencylanguagelexicosemanticnamingpreclinicalsubjective word‐finding complaintstau‐PET

Identifiers

PMID41816928
PMCPMC13093562

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.