ArticleFuture science OA2026
Isolation of plant-derived exosome-like nanovesicles (PDENs) from
Article in Future science OA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsChronic inflammation and ultraviolet (UV)-induced oxidative stress drive tissue damage and skin photoaging. This study evaluates MATERIALS &
methodsAv-PDENs were isolated via polyethylene glycol (PEG) precipitation and characterized by nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), and liquid chromatography-high-resolution mass spectrometry (LC-MS-HRMS). Anti-inflammatory activity was evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages by measuring nitric oxide, reactive oxygen species, interleukin-6, and macrophage polarization. Anti-photoaging effects were assessed in UVB-irradiated 1BR3 fibroblasts through ROS measurement, collagen type I expression and secretion, and scratch migration assay.
resultsAv-PDENs were spherical (mean diameter: 173 nm) and contained stress-response proteins. In macrophages, 40 µg/mL Av-PDENs reduced nitric oxide (NO) (46.90%) and reactive oxygen species (ROS) (28.67%), with decreasing trends in interleukin-6 and M1 polarization. In fibroblasts, 80 µg/mL Av-PDENs significantly decreased UVB-induced ROS by 43.55%. Notably, 40 µg/mL Av-PDENs restored collagen type I expression, increased secretion by 40.2%, and achieved 90% wound closure at 96 hours, significantly surpassing the 80 µg/mL group.
conclusionsOverall, Av-PDENs exhibit antioxidant, anti-inflammatory, and wound-healing activities, supporting potential cosmeceutical application.
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Registered trials
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