Evidence mapPaperPMID 41817300Full record

ArticleEuropean journal of immunology2026

Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota.

Chinna Susan Philip, Igor Filippov, Uku Haljasorg, Pärt Peterson

Abstract read
In one paragraph

Article in European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Chinna Susan PhilipMolecular Pathology Research Group, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Igor FilippovMolecular Pathology Research Group, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0003-2282-7773
Uku HaljasorgMolecular Pathology Research Group, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.
Pärt PetersonMolecular Pathology Research Group, Institute of Biomedicine and Translational Medicine, University of Tartu, Tartu, Estonia.ORCID 0000-0001-6755-791X

Funding

Estonian Research Council grants PRG2011Estonian Research Council grants TARISTU24-TK22EU Horizon WIDERA 2023 grant 101159920European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant 955321
6 · The paper itself

Abstract

Immune ageing impairs adaptive and innate responses, yet the spleen remains underexplored by cross-cohort single-cell studies. We profiled splenocytes from young, old and chronically stressed old mice with natural microbiota using single-cell RNA sequencing. Ageing was characterised by reduced lymphocyte competence and elevated stress responses. Within Gzmk

Indexed as

AgingCD8-Positive T-LymphocytesImmunosenescenceMicrobiotaSpleenStress, PhysiologicalAdaptation, PhysiologicalAnimalsKiller Cells, NaturalMacrophagesMiceMice, Inbred C57BLSingle-Cell AnalysisSingle-Cell Gene Expression AnalysisT-Cell Exhaustionageingchronic stressspleenT cellstranscriptomic

Identifiers

PMID41817300
PMCPMC12981209

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.