Evidence map›Paper›PMID 41817458›Full record

ArticleAnnals of the New York Academy of Sciences2026

Gatherings in Esophagology: Innovations and Future Directions in the Diagnosis and Management of Reflux Disease.

Jennifer Cable, Robert Giuli, Mark R Fox, Rachel L Rosen, Luis R Valdovinos-García, Stefano Siboni, John O Clarke, Nikki Johnston, Tina L Samuels, Carmelo Scarpignato and 29 more

Erratum issuedAbstract readConference Proceedings
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of the New York Academy of Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

39 authors.

Jennifer CableConsultant, The New York Academy of Sciences, New York, New York, USA.
Robert GiuliOESO, Paris, France.
Mark R FoxDepartment of Gastroenterology and Hepatology, University Hospital Zürich, Zürich, Switzerland.
Rachel L RosenAerodigestive Center, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
Luis R Valdovinos-GarcíaDepartamento de Cirugía Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
Stefano SiboniDivision of General and Emergency Surgery, IRCCS Policlinico San Donato, San Donato Milanese (Milan), University of Milan, Milan, Italy.
John O ClarkeDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Redwood City, California, USA.
Nikki JohnstonDepartment of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Tina L SamuelsDepartment of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Carmelo ScarpignatoDepartment of Health Sciences, United Campus of Malta, Birkirkara, Malta.
Ellen M SteinDepartment of Medicine, Robert Wood Johnson Medical School, Rutgers University, New Jersey, USA.
Ronnie FassDivision of Gastroenterology and Hepatology, Digestive Health Center, The Esophageal and Swallowing Center, MetroHealth Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.
José María Remes-TrocheLaboratorio de Fisiología Digestiva y Motilidad Gastrointestinal, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz, Mexico.
Abraham KhanDivision of Gastroenterology and Hepatology, NYU Grossman School of Medicine, NYU Langone Health, New York, USA.
Afrin K RahmanDivision of Gastroenterology and Hepatology, Stanford Medicine, Redwood City, California, USA.
Kristle LynchPerelman School of Medicine at the University of Pennsylvania, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Daniela JodorkovskyDivision of Gastroenterology and Hepatology, Icahn School of Medicine at Mount Sinai, New York, USA.
Marcelo F VelaDivision of Gastroenterology and Hepatology, Mayo Clinic Arizona, Scottsdale, Arizona, USA.
Alexandra VandenbergDepartment of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Braden KuoDivision of Digestive and Liver Disease, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
Pelin ErgunDepartment of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Pichamol JirapinyoDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Emanuele AstiDivision of General and Emergency Surgery, IRCCS Policlinico San Donato, San Donato Milanese (Milan), University of Milan, Milan, Italy.
Salvatore ToloneDepartment of Advanced Medical and Surgical Sciences, School of Medicine, University of Campania Luigi Vanvitelli, Naples, Italy.
Eric G SheuLaboratory for Surgical and Metabolic Research, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Renato SalvadorDepartment of Surgical, Oncological and Gastroenterological Sciences, University of Padova, Padua, Italy.
Marco SozziDivision of General and Emergency Surgery, IRCCS Policlinico San Donato, San Donato Milanese (Milan), University of Milan, Milan, Italy.
Inna A HusainPowers Health, Indiana University School of Medicine, Munster, Indiana, USA.
Justin C WuInstitute of Digestive Disease and State Key Laboratory of Digestive Diseases, The Chinese University of Hong Kong, Shatin, Hong Kong.
Anthony HobsonThe Functional Gut Clinic, London, UK.
Nirmal S SharmaDivision of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Wai-Kit LoDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Daniel R DuncanAerodigestive Center, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA.
C Prakash GyawaliDivision of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA.
Walter W ChanDivision of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Daniel SifrimWingate Institute for Neurogastroenterology, Queen Mary University of London, London, UK.
Edoardo SavarinoGastroenterology Unit, Department of Surgery, Oncology and Gastroenterology, University of Padua, Padua, Italy.
Nicola de BortoliGastrointestinal Unit-Department of Translational Sciences and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Benjamin D RogersDivision of Gastroenterology, Washington University School of Medicine, St. Louis, Missouri, USA.

Funding

Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin
6 · The paper itself

Abstract

Recent advances in the diagnosis and management of reflux disease were the central focus of the inaugural Gatherings in Esophagology (GiE), which convened experts across gastroenterology, surgery, otolaryngology, pulmonology, and basic research. The sessions highlighted innovations in reflux monitoring-including high-resolution manometry, wireless pH monitoring, and novel salivary biomarkers-while critically evaluating their diagnostic accuracy and clinical utility. Presentations explored the limitations of traditional proton-pump inhibitor therapy, the emergence of potassium-competitive acid blockers as a new class of acid suppressants, and the evolving role of adjunctive treatments such as mucosal protectants, reflux reducers, and neuromodulators for refractory symptoms. The discourse extended to advanced interventional procedures, including transoral incisionless fundoplication, magnetic sphincter augmentation, and the RefluxStop device, with discussion of patient selection, efficacy, and complication management. Discussants emphasized the pathophysiology and management of extraesophageal manifestations of reflux, the interplay between reflux and pulmonary disease, and the diagnostic challenges in pediatric populations. The meeting also addressed the integration of behavioral therapies, the role of the microbiome, and the application of artificial intelligence in reflux diagnostics. Collectively, these insights underscore a shift toward precision medicine in reflux disease, emphasizing individualized diagnostic strategies and tailored therapeutic approaches to improve patient outcomes.

Indexed as

GastroenterologyGastroesophageal RefluxEsophageal pH MonitoringFundoplicationHumansManometryProton Pump InhibitorsProton Pump Inhibitorsdiagnosisesophagologyfuture directionsGiEinnovationmanagementreflux disease

Identifiers

PMID41817458
PMCPMC12981296

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.