ReviewHeart failure reviews2026
Submaximal exercise metrics: Looking prior to VO₂max : in Heart Failure.
Review in Heart failure reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- New applications of cardiopulmonary exercise testing parameters characterize age-related changes in exercise performance during adolescence.Frontiers in cardiovascular medicine · 2026Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maximal oxygen uptake (VO₂max) remains the benchmark for cardiopulmonary exercise testing (CPET) in chronic heart failure (CHF). However, VO₂max and its surrogate, VO₂peak, often fail to capture the full spectrum of functional impairment, especially in patients unable to reach maximal effort. This review delineates submaximal CPET-derived metrics that offer valuable prognostic and diagnostic insights beyond VO₂max and are less dependent on peak effort. Guideline-endorsed parameters such as ventilatory anaerobic threshold (VAT) and the minute ventilation–carbon dioxide production slope (VE/VCO₂) are established tools for risk stratification and transplant evaluation. Emerging markers—including O₂ uptake efficiency slope (OUES), exertional oscillatory ventilation (EOV), O₂ pulse and cardiorespiratory optimal point (COP)—offer robust prognostic value in effort-limited populations. Additionally, O₂ uptake kinetics and extrapolated maximal oxygen consumption (EMOC) provide mechanistic perspectives on central and peripheral limitations, though their clinical integration remains early. Incorporating these submaximal metrics into composite risk models may enhance individualized care and improve outcomes in CHF.
Indexed as
Identifiers
41817819What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.