Evidence map›Paper›PMID 41818159›Full record

ArticleAmerican journal of physiology. Endocrinology and metabolism2026

Integrated glucagon model for estimation of α-cell responsivity to glucose and amino acids during graded glucose infusion.

Federica Boscolo, Sneha Mohan, Marcello C Laurenti, Jacob Kohlenberg, Hannah E Christie, Aoife M Egan, Adrian Vella, Chiara Dalla Man

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Federica BoscoloDepartment of Information Engineering, University of Padova, Padova, Italy.ORCID 0009-0003-0545-7288
Sneha MohanDivision of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-4840-1802
Marcello C LaurentiDivision of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-8697-6260
Jacob KohlenbergDivision of Diabetes, Endocrinology and Metabolism, University of Minnesota, Minneapolis, Minnesota, United States.ORCID 0000-0002-7157-0524
Hannah E ChristieDivision of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0002-0606-6778
Aoife M EganDivision of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, Minnesota, United States.
Adrian VellaDivision of Endocrinology, Diabetes and Metabolism, Mayo Clinic, Rochester, Minnesota, United States.ORCID 0000-0001-6493-7837
Chiara Dalla ManDepartment of Information Engineering, University of Padova, Padova, Italy.ORCID 0000-0002-4908-0596

Funding

Diabetes-Docs: Physician-Scientist Career Development Program (DiabDocs)K12DK133995 · NIDDK · STANFORD UNIVERSITY · PI LINDA A DIMEGLIO, David Matthew Maahs · 2022 to 2026
$16.0M
The regulation of fasting glucose metabolism in people with and without prediabetesR01DK078646 · NIDDK · MAYO CLINIC ROCHESTER · PI Adrian Vella · 2007 to 2026
$8.7M
Glucagon suppression and diabetes-associated variation in TCF7L2R01DK116231 · NIDDK · MAYO CLINIC ROCHESTER · PI Adrian Vella · 2017 to 2026
$5.4M
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK116231HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK78646NIDDK NIH HHS K12 DK133995NIDDK NIH HHS R01 DK078646NIDDK NIH HHS R01 DK116231
6 · The paper itself

Abstract

Pancreatic α-cells secrete glucagon. The glucagon secretion rate (GSR) increases when plasma glucose decreases; conversely, GSR decreases when glucose rises. In addition, amino acids (AAs) stimulate GSR. Impaired GSR suppression by glucose contributes to postprandial hyperglycemia in individuals with impaired glucose tolerance, obesity, and type 2 diabetes (T2D). However, the current method to assess α-cell responsivity to glucose ignores the contribution of AAs and is a two-step approach with some limitations. To address this, we developed a model-based method to quantify α-cell responsivity to glucose during a graded glucose infusion, in the presence and absence of AAs. A total of 52 subjects were studied. Thirty-seven subjects from

Indexed as

Amino AcidsGlucagonGlucagon-Secreting CellsGlucoseModels, BiologicalAdultBlood GlucoseFemaleHumansMaleMiddle AgedAmino AcidsBlood GlucoseGlucagonGlucosealpha cellglucagon secretionmodel selectionparameter estimation

Identifiers

PMID41818159
PMCPMC13080246

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.