ArticleAmerican journal of physiology. Heart and circulatory physiology2026
Reductions in myocardial interstitial fibrosis are dissociated from LV chamber stiffness in swine with repetitive pressure overload.
Article in American journal of physiology. Heart and circulatory physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cardiosphere-derived cells (CDCs) and the nonsteroidal aldosterone antagonist finerenone can each reduce myocardial fibrosis and have emerged as potential therapeutics for heart failure with preserved ejection fraction (HFpEF). Although these interventions can improve diastolic properties, their direct effects on left ventricular (LV) chamber stiffness have not been established. Accordingly, we examined their effect in swine with increased LV chamber stiffness and fibrosis from repetitive pressure overload (RPO). Swine (
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