Trial reportPloS one2026
Time restricted EAting for Type 2 diabetes and MEtabolic health: The TEA TIME trial study protocol.
Trial report in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07272460 (Time Restricted-eating and Metabolic Health in Patients With Type 2 Diabetes), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Time Restricted-eating and Metabolic Health in Patients With Type 2 Diabetes
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent findings have suggested that implementing the emerging weight-loss strategy of time-restricted eating (TRE) for 6 weeks can have beneficial effects on the key pathophysiologic determinants of type 2 diabetes (T2DM) - namely, pancreatic beta-cell function and insulin resistance. Given the chronic nature of T2DM and the general challenge of long-term adherence to dietary interventions, a critical question is the durability of such effects. Specifically, we seek to determine whether TRE can improve the metabolic health of patients with T2DM over 1 year.
methodsIn this open-label, parallel-arm, randomized controlled trial, individuals with overweight/obesity and T2DM of <10 years duration will be randomized to either standard lifestyle recommendations or TRE. The TRE protocol will consist of 18 hours of fasting and a 6 hour window of eating (between 2-8 PM) each day. The duration of the intervention will be 52-weeks and participants will undergo metabolic characterization at baseline, 12-24-, 36- and 52-weeks. The primary outcome of pancreatic beta-cell function will be assessed by Insulin Secretion-Sensitivity Index-2 (ISSI-2). Additional metabolic measures will include insulin resistance and glucose homeostasis. DISCUSSION: TRE may represent an adjunct therapeutic approach for improving the metabolic profile of overweight/obese individuals with T2DM while also providing the capacity for modification of its underlying pathophysiology. This evaluation of the durability of the metabolic effects of TRE on beta-cell function and insulin resistance could thus identify a role for this dietary strategy as a disease-modifying intervention early in the course of T2DM.
trial registrationclinicaltrials.gov NCT07272460.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.