Evidence map›Paper›PMID 41818678›Full record

ReviewEuropean heart journal. Acute cardiovascular care2026

Managing bleeds on anticoagulant therapy: a practical guide for clinicians.

Mattia Galli, Beatrice Simeone, Jurrien Ten Berg, Davide Capodanno, Marco Valgimigli, Sebastiano Sciarretta, Ernesto Greco, Adnan Kastrati, Gilles Montalescot, C Michael Gibson and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European heart journal. Acute cardiovascular care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Antiplatelet therapy on top of anticoagulation in atrial fibrillation: when less may be more.International journal of cardiology. Heart & vasculature · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mattia GalliDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica, 79, Latina 04100, Italy.ORCID 0000-0003-3909-182X
Beatrice SimeoneDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica, 79, Latina 04100, Italy.
Jurrien Ten BergDepartment of Cardiology, St.Antonius Hospital, Nieuwegein, the Netherlands.
Davide CapodannoDivision of Cardiology, Azienda Ospedaliero-Universitaria Policlinico Rodolico-San Marco, University of Catania, Catania, Italy.
Marco ValgimigliCardiocentro Ticino Institute, Ente Ospedaliero Cantonale, University of Italian Switzerland, Lugano, Switzerland.
Sebastiano SciarrettaDepartment of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Corso della Repubblica, 79, Latina 04100, Italy.
Ernesto GrecoDepartment of Health and Life Sciences, European University of Rome, Rome, Italy.
Adnan KastratiKlinik für Herz- und Kreislauferkrankungen, TUM Klinikum Deutsches Herzzentrum, Technische Universität München, Munich, Germany.ORCID 0000-0003-4341-891X
Gilles MontalescotACTION Study Group, INSERM UMRS1166, Sorbonne Université, Hôpital Pitié-Salpêtrière (AP-HP), Paris, France.
C Michael GibsonBaim Institute for Clinical Research, Harvard Medical School, Harvard University, Boston, MA, USA.
Diana A GorogDepartment of Cardiology, University of Hertfordshire, Hatfield, Hertfordshire, UK.
Roxana MehranMount Sinai Fuster Heart Hospital, Icahn School of Medicine at Mount Sinai, NewYork, NY, USA.ORCID 0000-0002-5546-262X
Dominick J AngiolilloDivision of Cardiology, University of Florida College of Medicine, 655 West 8th Street-Jacksonville, Jacksonville, FL 32209, USA.ORCID 0000-0001-8451-2131

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bleeding is a prevalent and frequently serious complication of anticoagulant therapy. The use of oral anticoagulants to prevent thrombotic events in common cardiovascular conditions, such as atrial fibrillation, exposes patients to an increased risk of bleeding which is associated with morbidity and mortality. The consequences of bleeding extend well beyond the acute event, affecting treatment adherence, long-term management decisions, and increasing the risk of ischaemic events when anticoagulation is discontinued. Optimizing the balance between thrombotic and bleeding risk requires expertise in risk stratification, preventive strategies, acute management, and the appropriate timing of anticoagulation resumption after haemostasis. This review summarizes the epidemiology and clinical impact of bleeding in patients receiving oral anticoagulant therapy and provides contemporary, patient-centred flowcharts for acute management and safe resumption of treatment. Future efforts should focus on refining risk prediction, individualizing anticoagulant regimens, and improving access to targeted reversal agents to further improve patient outcomes.

Indexed as

AnticoagulantsHemorrhagePractice Guidelines as TopicAdministration, OralHumansRisk AssessmentAnticoagulantsAnticoagulant therapyAnticoagulationBleedingHaemostasisReversal strategiesRisk stratification

Identifiers

PMID41818678
PMCPMC13344178

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.