Evidence map›Paper›PMID 41820699›Full record

ArticleAnalytical and bioanalytical chemistry2026

Development of a monoclonal antibody-based time-resolved fluorescence immunochromatographic assay strip for rapid and quantitative determination of S100B in serum.

Rui Feng, Yupeng Wang, Yonghua Chen, Tianxu Li, Houfeng Zhou, Zhenye Zhan, Yuying He, Xialin Tang, Jianfen Su, Yuhuai Guo and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rui FengSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong, China.
Yupeng WangSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong, China.
Yonghua ChenThe Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Tianxu LiSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong, China.
Houfeng ZhouThe Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Zhenye ZhanThe Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Yuying HeSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong, China.
Xialin TangDepartment of Neurology, Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China.
Jianfen SuThe Affiliated Panyu Central Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
Yuhuai GuoWomen and Children's Medical Center Affiliated to Guangzhou Medical University, Guangzhou, Guangdong, China.
Xiaomin ChenDepartment of Neurology, Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China.
Jie ZanSchool of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou, Guangdong, China. zanj@gdut.edu.cn.

Funding

Administration of Traditional Chinese Medicine of Hubei Province for provincial TCM Innovation Team Project ZY2025L001
6 · The paper itself

Abstract

Traumatic brain injury (TBI) represents a significant global health challenge requiring rapid and accurate diagnostic tools. S100 calcium-binding protein B (S100B) serves as a consensus-endorsed serum biomarker for TBI, but current detection methods lack the speed and simplicity needed for on-site clinical applications. This study reports the development of a time-resolved fluorescence immunochromatographic test strip (TRFIS) for rapid and quantitative serum S100B detection. High-affinity monoclonal antibodies against S100B were generated via hybridoma technology, and time-resolved fluorescent microspheres (TRFMs) were integrated with lateral flow immunoassay. The TRFIS demonstrated excellent analytical performance with a linear range of 15.6-1000 pg/mL (R

Indexed as

Antibodies, MonoclonalBrain Injuries, TraumaticChromatography, AffinityS100 Calcium Binding Protein beta SubunitAnimalsFluorescenceHumansImmunoassayLimit of DetectionMiceMice, Inbred BALB CMicrospheresRapid Diagnostic TestsReagent StripsReproducibility of ResultsAntibodies, MonoclonalReagent StripsS100B protein, humanS100 Calcium Binding Protein beta SubunitS100 calcium-binding protein BTime-resolved fluorescence immunochromatographic test stripTraumatic brain injury

Identifiers

PMID41820699

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.