Evidence map›Paper›PMID 41820730›Full record

ArticleSports medicine - open2026

Vagal Activity and Fat Oxidation Basal Correlates in Older Active Postmenopausal Women: A Cross-Sectional Study.

Jordi Monferrer-Marín, Ainoa Roldán, Jørn Wulff Helge, Cristina Blasco-Lafarga

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sports medicine - open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06336070 (Postmenopausal Oncological Women Exercising for Recover Their Health. Associations and Changes in Metabolic Flexibility and Autonomic Control After Two Training Programs), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06336070 narecruitingnot on this map

Postmenopausal Oncological Women Exercising for Recover Their Health. Associations and Changes in Metabolic Flexibility and Autonomic Control After Two Training Programs (Muscle Power vs Metabolic Power): the POWER Health Study

TypeinterventionalSponsorUniversity of ValenciaRan2024 to 2028Enrolled56ConditionsBreast Cancer Female, Cardiometabolic Syndrome, Metabolism Disorder, Lipid, Autonomic DysfunctionArmsHIIT program (8 weeks), MPI program (8 weeks)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jordi Monferrer-MarínSport Performance and Physical Fitness Research Group (UIRFIDE), Physical Education and Sports Department, University of Valencia, Valencia, Spain.ORCID https://orcid.org/0000-0001-9869-5936
Ainoa RoldánSport Performance and Physical Fitness Research Group (UIRFIDE), Physical Education and Sports Department, University of Valencia, Valencia, Spain.ORCID https://orcid.org/0000-0001-7190-7943
Jørn Wulff HelgeDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID https://orcid.org/0000-0001-9724-5423
Cristina Blasco-LafargaSport Performance and Physical Fitness Research Group (UIRFIDE), Physical Education and Sports Department, University of Valencia, Valencia, Spain. m.cristina.blasco@uv.es.ORCID http://orcid.org/0000-0001-8798-306X

Funding

Conselleria d'Educació, Universitats i ocupació. Generalitat Valenciana 2023-2027Conselleria d'Educació, Universitats i ocupació. Generalitat Valenciana CIACIF/2022/368
6 · The paper itself

Abstract

backgroundHeart Rate Variability at rest has been recently associated with metabolic outcomes alongside exercise, which in turn have been associated with energy expenditure, muscle power and fat mass. This study aimed to analyse the relationship at rest between autonomic function and metabolic outcomes, in physically active postmenopausal women. We hypothesised that, autonomic function is more strongly associated with Fat oxidation than basal metabolic rate. In sixty-one active postmenopausal women (67.9 ± 5.3 years; 40.3 ± 4.3 kg muscle mass) basal metabolic rate and Heart Rate Variability analysis was recorded simultaneously for 30 min with participants resting supine under standardised activity and diet conditions.

resultsRoot Mean Square of Successive Differences of heart beats (RMSSD) and Total power showed a predictive value for resting Fat oxidation (β = 0.46; β = 0.26), explaining 30% of the variance. Including traditional predictors such as energy expenditure increased explained variance to 57.5%. In this model, RMSSD association disappeared, Total power (β = 0.88) became the strongest predictor, and together with energy expenditure (β = 0.53), showed significant associations with FATox. Respiratory exchange ratio only correlated with RMSSD (β = - 0.54) in the isolated Heart Rate Variability model, without basal metabolic rate associations. Box plots of RMSSD quartiles revealed a difference in fat-oxidation between the highest and lowest quartiles, a pattern not seen for Total power.

conclusionBaroreflex activity and fat oxidation associate at rest in active postmenopausal women with preserved cardiovascular function. Total power emerges as the strongest Heart Rate Variability predictor of baseline Fat oxidation in the multivariable models. Stratification by RMSSD quartiles revealed graded differences in fat oxidation rates across levels of vagal modulation.

trial registrationClinical Trials, NCT06336070. https://clinicaltrials.gov/study/NCT06336070 Registered: 4 April 2024.

Indexed as

Autonomic nervous systemBaroreflexEnergy expenditureHeart rate variabilityMetabolic flexibilityTotal powerVagus nerve

Identifiers

PMID41820730
PMCPMC12982731

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.