SynthesisStem cell reviews and reports2026
The Role of MicroRNA in the Behaviour of Periodontal Ligament Stem Cells and Stem Cells from the Apical Papilla: A Systematic Review.
Synthesis in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
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Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis systematic review aimed to synthesize current evidence on the regulatory role of microRNAs (miRNAs) in the viability, proliferation, osteo-odontogenic differentiation potential and/or inflammation of periodontal ligament stem cells (PDLSCs) and stem cells from the apical papilla (SCAPs), with a focus on their potential in periodontal and endodontic regeneration. METHODOLOGY: A comprehensive search across Medline, Scopus, Embase, Web of Science, and SciELO databases up to December 2025 identified original in vitro studies assessing miRNA overexpression or knockdown in PDLSCs or SCAPs. 39 studies met the eligibility criteria and underwent structured data extraction, qualitative synthesis and quality appraisal using a tailored risk-of-bias tool (miRoB-DSC).
resultsThe findings demonstrate that specific miRNAs act as key regulators of PDLSCs and SCAPs viability, proliferation, osteo-odontogenic differentiation, and inflammatory responses. Comparisons with previous reviews on DPSCs and PDLSCs suggest both shared and niche-specific regulatory networks. Various signaling pathways have been majorly implicated with miRNA regulation, including RUNX2, Smad/TGFβ, NOTCH, NF-κB, Wnt/β-catenin and MAPK. The majority of the assessed studies fulfilled more than 80% of the applicable items from the miRoB-DSC tool.
conclusionCollectively, these results highlight miRNAs as central modulators of PDLSC and SCAP biology, with potential applications as therapeutic targets or biomarkers in regenerative dentistry. However, heterogeneity in experimental designs, limited evaluation under disease-relevant conditions, and the reliance on in vitro models highlight the need for standardized protocols and in vivo validation before clinical translation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.