Evidence map›Paper›PMID 41821087›Full record

ArticleBMC pharmacology & toxicology2026

Melatonin mitigates methamphetamine-induced testicular oxidative stress, hormonal imbalance and seminiferous tubule degeneration in rats.

Abubakar Lekan Imam, Banmore Oyinlola Adebola, Fatimo Ajoke Sulaimon, Kehinde Muibat Ibiyeye, Aliyu Ibrahim Adedo, Rukayat Jaji-Sulaimon, Olarewaju Ambali Danwahab, Abdussalam Babalola Abdulsalam, Gabriel Olaiya Omotoso, Moyosore Salihu Ajao

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Article in BMC pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Abubakar Lekan ImamDepartment of Anatomy, University of Ilorin, Ilorin, Nigeria. Imam.al@unilorin.edu.ng.ORCID http://orcid.org/0009-0000-3111-7461
Banmore Oyinlola AdebolaDepartment of Anatomy, University of Ilorin, Ilorin, Nigeria.
Fatimo Ajoke SulaimonDepartment of Anatomy, University of Ilorin, Ilorin, Nigeria.
Kehinde Muibat IbiyeyeDepartment of Anatomy, University of Ilorin, Ilorin, Nigeria.
Aliyu Ibrahim AdedoDepartmment of Medical Biochemistry, University of Ilorin, Ilorin, Nigeria.
Rukayat Jaji-SulaimonDepartment of Anatomy, University of Ilorin, Ilorin, Nigeria.
Olarewaju Ambali DanwahabDepartment of Anatomy, Kwara State University, Malete, Nigeria.
Abdussalam Babalola AbdulsalamDepartment of Anatomy, University of Ilorin, Ilorin, Nigeria.
Gabriel Olaiya OmotosoDepartment of Anatomy, University of Ilorin, Ilorin, Nigeria.
Moyosore Salihu AjaoDepartment of Anatomy, University of Ilorin, Ilorin, Nigeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDrug abuse has become a significant public health concern due to its effects on socioeconomic and mental health challenges. Methamphetamine (MAP) is a common psychostimmulant drug consume widely by youth. it excites central nervous system, alters neurotransmiters and affects body tissues including testis. This study examined the effects of melatonin on methamphetamine-induced testicular toxicity in adult rats.

methodsThirty-two (32) adult male Wistar rats (130 ± 2.70 g) were used were randomly assigned into four (4) groups of 8 animals each. Group 1 was given 0.5 ml/kg of phosphate buffered saline (PBS); group II received 20 mg/kg of MAP; group III was administered 10 mg/kg of MAP; and group IV was given 20 mg/kg of MAP plus 10 mg/kg of MAP. All the administration was carried out orally using oral cannula and lasted for 21 days. After the administration, oxidative stress level, Hormonal concentration, seminal fluid parameters were assayed. Histological analysis of the testis was done using H & E stain.

resultsMelatonin was able to improved antioxidant capacity of Superoxide Dismutase (SOD) and Glutathione Peroxidase (GPx), and reduced Malondialdehyde (MDA) concentration. It also regulate the hormonal concentration of LH, FSH and testosterone and enhanced the caudal epididymal sperm quality and restored testicular morphology.

conclusionMelatonin showed an antioxidant effects against methamphetanine-induced testicular toxicity and improve testicular functions in rat. Therefore melatonin has a therapeutic benefit against methamphetamine toxicity.

Indexed as

AntioxidantsCentral Nervous System StimulantsMelatoninMethamphetamineSeminiferous TubulesTestisAnimalsGlutathione PeroxidaseLuteinizing HormoneMaleMalondialdehydeOxidative StressRatsRats, WistarSuperoxide DismutaseTestosteroneAntioxidantsCentral Nervous System StimulantsGlutathione PeroxidaseLuteinizing HormoneMalondialdehydeMelatoninMethamphetamineSuperoxide DismutaseTestosteroneGlutathione peroxidaseMelatoninMethamphetamineSeminal fluid

Identifiers

PMID41821087
PMCPMC13097839

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.