Evidence mapPaperPMID 41821152Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Engineering MnPt Bimetallic Nanozymes for Cascade Enzymatic Therapy and Enhanced Radio-Immunotherapy.

Wenyi Zhang, Yangyang Guo, Guoping Xu, Luhaoxiang Liu, Lin Chen, Cai Zhang, Yiming Li, Jianmin Li, Yang Zhao

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenyi ZhangDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0009-0000-9641-4248
Yangyang GuoDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Guoping XuDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Luhaoxiang LiuDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Lin ChenDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Cai ZhangDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Yiming LiDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Jianmin LiTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Yang ZhaoDepartment of Radiology, The Second Hospital of Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0003-4656-172X

Funding

Medical Key Discipline Program of Tianjin Municipal Healthcare Commission TJYXZDXK-070CNational Natural Science Foundation of China 81872106National Natural Science Foundation of China 82272804National Natural Science Foundation of China 91959114Natural Science Foundation of Tianjin 22JCQNJC01700Scientific and Technological Research Program of Tianjin Health Commission TJWJ2022XK015
6 · The paper itself

Abstract

The immunosuppressive tumor microenvironment (TME) promotes resistance to radiation therapy, substantially limiting the efficacy of radioimmunotherapy. Here, we report a hyaluronic acid (HA)-coated manganese-platinum (MnPt) bimetallic nanozyme (HD@MnO

Indexed as

Breast NeoplasmsImmunotherapyManganesePlatinumRadioimmunotherapyAnimalsCell Line, TumorcGAS-STING Signaling PathwayFemaleHumansHyaluronic AcidManganese CompoundsMiceOxidesTumor MicroenvironmentHyaluronic AcidManganeseManganese CompoundsOxidesPlatinumcascade enzymatic activitycGAS‐STINGimmunogenic cell deathnanozymeradioimmunotherapy

Identifiers

PMID41821152
PMCPMC13159110

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.