Evidence map›Paper›PMID 41821185›Full record

Observational studyBritish journal of haematology2026

Dose-dependent impairment of brain functional and microstructural connectivity during leukaemia chemotherapy.

Ashleigh P Scott, Ada Lo, Ying Xia, Kate Thompson, Harriet Bodimeade, Amir Fazlollahi, Nicholas Weber, Cameron Curley, Stewart Hunt, Kirk Morris and 8 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in British journal of haematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ashleigh P ScottDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.ORCID https://orcid.org/0000-0001-5574-6713
Ada LoDepartment of Psychology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Ying XiaThe Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, Queensland, Australia.
Kate ThompsonDepartment of Psychology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Harriet BodimeadeDepartment of Psychology, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Amir FazlollahiQueensland Brain Institute, The University of Queensland, Brisbane, Queensland, Australia.
Nicholas WeberDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Cameron CurleyDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Stewart HuntDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Kirk MorrisDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Caroline McNamaraDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Nilu PereraDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.ORCID https://orcid.org/0000-0002-4752-0551
Elango SubramoniapillaiDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Steven W LaneDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Glen A KennedyDepartment of Haematology and Bone Marrow Transplant, Royal Brisbane and Women's Hospital, Herston, Queensland, Australia.
Olivier SalvadoQueensland University of Technology, Brisbane, Australia.
Javier UrriolaThe Australian e-Health Research Centre, CSIRO Health and Biosecurity, Brisbane, Queensland, Australia.
Katie L McMahonSchool of Clinical Sciences and Herston Imaging Research Facility, Queensland University of Technology, Brisbane, Queensland, Australia.

Funding

Royal Brisbane and Women's Hospital Foundation 18/QRBW/45522
6 · The paper itself

Abstract

'Chemobrain' language symptoms are commonly reported by adults receiving intensive chemotherapy for acute myeloid leukaemia (AML), but real-time detection eludes clinical imaging modalities. We performed a prospective, observational, longitudinal cohort study employing serial comprehensive neurocognitive assessment and brain functional MRI (fMRI) in 20 adults receiving intensive chemotherapy for newly diagnosed AML. At chemotherapy completion, fMRI demonstrated significantly reduced functional connectivity between the salience (anterior cingulate cortex [ACC]) and the left language (inferior frontal gyrus [IFG] and posterior superior temporal gyrus [pSTG]) networks (p = 0.008), supported by significant decreases in white matter fibre density in the corpus callosum (p = 0.009) and in the tract connecting the ACC and left IFG (p = 0.037). Increasing cytarabine dose significantly correlated with decreasing ACC-IFG connectivity (R

Indexed as

BrainLeukemia, Myeloid, AcuteAdultAgedCytarabineDose-Response Relationship, DrugFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesCytarabinefMRIleukaemianeurotoxicity

Identifiers

PMID41821185
PMCPMC13176540

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.