Evidence map›Paper›PMID 41821218›Full record

ArticleMolecular microbiology2026

Gut Microbiota-Derived Extracellular Vesicles in Patients With Obesity Undergoing Gastric Bypass Surgery.

Jenni Hekkala, Anna Kaisanlahti, Mysore V Tejesvi, Jenni Turunen, Nikke Virtanen, Sonja Karikka, Pande Putu Erawijantari, Anatoliy Samoylenko, Genevieve Bart, Seppo Vainio and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00950003, which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00950003 no registry record found
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jenni HekkalaResearch Unit of Translational Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0002-5826-1196
Anna KaisanlahtiResearch Unit of Translational Medicine, University of Oulu, Oulu, Finland.
Mysore V TejesviBiocenter Oulu, University of Oulu, Oulu, Finland.
Jenni TurunenBiocenter Oulu, University of Oulu, Oulu, Finland.ORCID 0000-0002-4158-7026
Nikke VirtanenResearch Unit of Translational Medicine, University of Oulu, Oulu, Finland.
Sonja KarikkaResearch Unit of Translational Medicine, University of Oulu, Oulu, Finland.
Pande Putu ErawijantariDepartment of Computing, University of Turku, Turku, Finland.
Anatoliy SamoylenkoLaboratory of Developmental Biology, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0002-0240-897X
Genevieve BartLaboratory of Developmental Biology, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Seppo VainioLaboratory of Developmental Biology, Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, University of Oulu, Oulu, Finland.
Leo LahtiDepartment of Computing, University of Turku, Turku, Finland.
Janne HukkanenResearch Unit of Biomedicine and Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Terhi Ruuska-LoewaldBiocenter Oulu, University of Oulu, Oulu, Finland.ORCID 0000-0001-5433-4207
Vesa KoivukangasResearch Unit of Clinical Medicine, University of Oulu, Oulu, Finland.ORCID 0000-0002-2966-0286
Justus ReunanenResearch Unit of Translational Medicine, University of Oulu, Oulu, Finland.

Funding

Biocenter Oulu, University of OuluDiabetestutkimussäätiöSuomen Lääketieteen SäätiöSuorsan terveydenhuoltosäätiöSydäntutkimussäätiö
6 · The paper itself

Abstract

Human gut microbiota is associated with obesity. Gut microbiota-derived extracellular vesicles (EVs), lipid coated nanoparticles secreted by bacteria, have been suggested as a communication mechanism between gut microbiota and the host. This study characterized the effect of Roux-en-Y gastric bypass (RYGB) on gut microbiota and gut microbiota-derived EVs in patients with obesity. Fecal samples were collected from 30 recruited patients at baseline and 6 months after surgery. EVs were isolated from fecal samples, and their origin and protein content were analyzed. The number of unique proteins was increased in gut microbiota-derived EVs after the surgery as compared to baseline. A significant difference in both microbiota composition (p = 0.001; PERMANOVA) and microbiota-derived EVs (p = 0.001; PERMANOVA) was observed in response to surgery. Based on 16S rRNA gene sequencing data, a random forest classifier accurately classified both gut microbiota (AUC = 0.93) and EVs (AUC = 0.80) to baseline and after surgery groups. This study found that gastric bypass surgery altered both the composition and characteristics of gut microbiota and gut microbiota-derived EVs in patients with obesity. Thus, gut microbiota-derived EVs may play a role in obesity and influence the health effects of bariatric surgery beyond the gut. Trial Registration: ClinicalTrials.gov identifier: NCT00950003.

Indexed as

Extracellular VesiclesGastric BypassGastrointestinal MicrobiomeObesityAdultBacteriaFecesFemaleHumansMaleMiddle AgedRNA, Ribosomal, 16SRNA, Ribosomal, 16Sextracellular vesiclesgastric bypass surgerygut microbiotananoparticlesobesity

Identifiers

PMID41821218
PMCPMC13135909

What Socratic holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.