ArticleAndrology2026
Testicular SIRT1 Loss Reveals an Aging-Like Proteomic Landscape and Precipitates Reproductive Deterioration.
Article in Andrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- SIRT1 haploinsufficiency recapitulates age-associated subfertility through sperm α-tubulin hyperacetylation.Biology direct · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundAdvanced paternal age is associated with reduced male fertility and testicular dysfunction. Among the molecular regulators involved in aging, SIRT1, a NAD
objectiveThis study aimed to determine whether testicular SIRT1 insufficiency contributes to testicular aging by promoting changes in the proteomic landscape and impairing male reproductive function. MATERIALS AND
methodsWe employed a Sirt1
resultsSirt1 DISCUSSION: Our findings indicate that partial loss of SIRT1 is sufficient to trigger proteomic and functional hallmarks of testicular aging. In particular, we identified specific proteomic signatures linked to subfertility, including the loss of key capacitation-related proteins regulated by SIRT1 in the testis, a pattern also observed in aged animals, which may represent a mechanistic model of SIRT1-governed fertilization failure.
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Registered trials
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