ArticleUlusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES2026
Effect of calcium dobesilate on liver regeneration in rats undergoing partial hepatectomy.
Article in Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo date, no study has evaluated the effects of calcium dobesilate on regenerative capacity after partial hepatectomy. Within the scope of this research, we aimed to elucidate the effects of calcium dobesilate (CD) on liver regeneration capacity and antioxidant pathways after partial hepatectomy.
methodsThirty-six Sprague Dawley male rats weighing between 250-350 grams were used in the study. All animals underwent partial hepatectomy. The rats were randomly divided into four groups, each consisting of nine rats, as control groups (Groups 1 and 2) and study groups (Groups 3 and 4). Regeneration rate, histopathological parameters, immunohistochemical examination, and the apoptotic index (AI) were measured.
resultsTissue superoxide dismutase (SOD) levels were statistically significantly higher in the calcium dobesilate study groups compared to controls (p=0.03). Malondialdehyde (MDA) levels were statistically significantly higher in the study groups than in the control groups on both the second and seventh days (p=0.001). The regeneration rate (RR) was higher in the study group compared to the control group on the second day, and this difference was statistically significant (p<0.001). RR was also significantly higher in the study group on the second day compared to the seventh day (p<0.001). According to the Suzuki Scoring System, vacuolization and necrosis were not observed in the study groups (p<0.001 vs. p=0.034, respectively). The apoptotic index was significantly higher in the control groups compared to the study groups (p<0.001), and AI was statistically significantly lower on the seventh day (p=0.006). Ki-67 expression was statistically significantly higher in the groups receiving CD treatment on both the second and seventh days. In the control groups, Ki-67 expression was statistically significantly higher on the seventh day compared to the second day (p=0.006).
conclusionThis research indicated the effects of calcium dobesilate on improving oxidative damage and liver regeneration in rats undergoing partial hepatectomy. The results of the present study showed that (preoperative-postoperative) CD improves oxidative stress and increases liver regeneration capacity after partial hepatectomy.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.